Hemostatic, bone impairment renovation material with bioactivity

A repair material and bioactive technology, applied in medical science, prosthesis, etc., can solve problems such as repair of bone wounds and defects, and achieve good hemostatic function, good cell affinity, good biological activity and biocompatibility sexual effect

Inactive Publication Date: 2010-02-24
杨春蓉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there are no domestic and foreign patent literature reports on the application of bioactive glass, collagen, chitosan and lecithin in coagulation materials, wound treatment and bone defect repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Bioactive glass nanopowder, collagen solution, chitosan powder and lecithin were selected to prepare bioactive materials for hemostasis and bone defect repair. Its preparation process is as follows:

[0024] (1) Mix bioactive glass nano powder, collagen solution, chitosan powder and lecithin in proportion, and stir evenly. The mass percent content of each component is respectively: 50% of bioactive glass nanometer powder, 30% of collagen, 10% of chitosan, and 10% of lecithin.

[0025] (2) In the mixed solution of bioactive glass nanopowder, collagen solution, chitosan powder and lecithin, ethylenesulfonic acid is used as a buffer, with 2mg / ml of 1-ethyl-3-(3 -Dimethylaminopropyl) carbodiimide and 0.5 mg / ml N-hydroxysuccinimide are used as crosslinking agents to carry out crosslinking treatment on the mixed solution, and the pH value of the solution is adjusted to be 5. .

[0026] (3) Put the above-mentioned cross-linked mixed solution into a freezer at -30°C for 15 h...

Embodiment 2

[0031] Bioactive glass nanopowder, collagen solution, chitosan powder and lecithin were selected to prepare bioactive materials for hemostasis and bone defect repair. Its preparation process is as follows:

[0032] (1) Mix bioactive glass nano powder, collagen solution, chitosan powder and lecithin in proportion, and stir evenly. The mass percent content of each component is respectively: 55% of bioactive glass nanometer powder, 25% of collagen, 12% of chitosan, and 8% of lecithin.

[0033] (2) In the mixed solution of bioactive glass nanopowder, collagen solution, chitosan powder and lecithin, ethylenesulfonic acid is used as a buffer, with 1.5mg / ml of 1-ethyl-3-( 3-Dimethylaminopropyl) carbodiimide and 0.4 mg / ml N-hydroxysuccinimide were used as cross-linking agents to carry out cross-linking treatment on the mixed solution, and the pH value of the solution was adjusted to 5.5.

[0034] (3) Put the above-mentioned cross-linked mixed solution into a freezer at -25° C. for 2...

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Abstract

The invention relates to a material used to stop blooding and repair the skeleton, with biological activity. The invention is characterized in that it comprises 45-60% biological active glass nanometer powder, 25-40% of collagen, 8-15% of chitose, and 8-15% of lecithin, to be mixed, crosslink, frozen and dried in vacuum. The invention has the functions as blooding stop and skeleton repair, withouttoxicity while it is degradable in sponge or powder shape. The invention has wide application.

Description

technical field [0001] The invention relates to a biologically active material for hemostasis and bone defect repair, which belongs to the technical field of biomedical materials. Background technique [0002] Local hemostatic materials are widely used in surgical hemostasis, and the research and application of local hemostatic drugs have developed rapidly in recent years. However, for wounds with deep wounds and bone tissue defects, the materials developed in recent years have poor biological functions in terms of hemostasis and healing promotion, and do not have the function of rapid repair of bone defects. Therefore, the development and use of a new generation of functional hemostasis and bone repair materials is still a worldwide problem. [0003] Bioactive glasses are a class of inorganic active materials widely used in bone repair. They have good biocompatibility, no toxic side effects, and because their chemical composition is similar to the natural bones of organis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/54A61L27/60
Inventor 杨春蓉
Owner 杨春蓉
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