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Application of turmeric element in the preparation of medicament for restraining uric acid transportor URAT1

A technology of curcumin and transporter is applied in the application field of curcumin in the preparation of uric acid transporter URAT1 inhibitory drugs, and achieves the effects of clear action target, good safety and definite active ingredients

Active Publication Date: 2009-12-23
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of the monomer compound curcumin to prepare inhibitory drugs against the uric acid transporter URAT1 has not been reported.

Method used

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  • Application of turmeric element in the preparation of medicament for restraining uric acid transportor URAT1
  • Application of turmeric element in the preparation of medicament for restraining uric acid transportor URAT1
  • Application of turmeric element in the preparation of medicament for restraining uric acid transportor URAT1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Inhibition and regulation of flavonoid monomer compound curcumin on uric acid transporter URAT1

[0016] Experimental animals: Kunming mice, 15-20 grams, male

[0017] Drug preparation: curcumin is uniformly dispersed in normal saline for intragastric administration, and the dosage is 25mg / kg

[0018] Experimental materials: Trizol Reagment (Invigen), chloroform, isopropanol, absolute ethanol, DEPC, M-MLV

[0019] Reverse transcriptase, PCR kit, RIPA lysate, etc.

[0020] Experimental equipment: high-speed refrigerated centrifuge, high-speed homogenizer, Bio-rad vertical electrophoresis tank, MBI-PCR instrument, horizontal electrophoresis tank, etc.

[0021] Experimental model: mouse hyperuricemia model.

[0022] experimental method:

[0023] 1. Establishment of the model: After one week of adaptation to the environment, the animals were given oxonic acid potassium salt 250 mg / kg by intragastric administration; the control group was given an equal volume ...

Embodiment 2

[0038] The monomer compound curcumin is dissolved in water and an appropriate amount of solubilizer (polyethylene glycol 400) according to the conventional preparation method, subpackaged, sterilized, and prepared into a curcumin oral liquid whose specification is 20 mg / ml;

[0039] The monomer compound curcumin is prepared into curcumin capsules with a specification of 20 mg / grain according to the conventional preparation method, and the soft capsule material is selected from gelatin and sorbitol;

[0040] The monomer compound curcumin was prepared according to the conventional preparation method, and the excipient cyclodextrin was added, mixed uniformly, granulated, compressed into tablets, and prepared into curcumin tablets with a specification of 20 mg / tablet.

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Abstract

The invention relates to a new application of curcumin, a flavonoid monomer compound, in particular to the application of curcumin in the preparation of uric acid transporter URAT1 inhibitory drugs. The results of animal experiments show that curcumin has a definite inhibitory effect on the expression of uric acid transporter URAT1, which is abnormally increased in hyperuricemia model animals, but has no significant inhibitory effect on the normal level of uric acid transporter URAT1 expression in normal animals. Safety, using curcumin with related pharmaceutical excipients, conventional preparation methods can be used to make curcumin oral liquid, capsules, tablets, granules and other uric acid transporter URAT1 inhibitory drugs, which can be used for the treatment of uric acid transporter Diseases associated with abnormally high expression of sub-URAT1.

Description

Technical field: [0001] The invention relates to a new application of curcumin, a flavonoid monomer compound, in particular to the application of curcumin in the preparation of uric acid transporter URAT1 inhibitory drugs. Background technique: [0002] Decreased excretion or increased production of uric acid can lead to increased uric acid concentration in the blood, directly or indirectly causing related diseases. The excretion of uric acid is a complex process. When uric acid flows into the glomerulus with the blood circulation, the free uric acid will be completely filtered; about 99% of the uric acid is reabsorbed in the proximal renal tubule (Diamond HS, Meisel AD. Postsecretory reabsorption of urate in man. Arthritis And Rheumatism, 1975, 18(6): 805-809.). The uric acid transporter (protein) URAT1 located in the proximal convoluted tubule participates in the uric acid reabsorption process, and transports urate from the lumen into the cell by exchanging with anions. ...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P19/06
Inventor 孔令东潘颖李建梅王闯
Owner NANJING UNIV
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