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Use of kerato cell growth factor-2 in treatment of chronic cervicitis medicine

A technology for chronic cervicitis and growth factors, applied in the pharmaceutical field, can solve the problems of inconvenience in daily life of patients, affecting adverse reactions, and long healing time, and achieve the effects of no sequelae, good effect, and simple and easy production process.

Inactive Publication Date: 2009-10-21
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, various physical treatments are often used clinically, such as freezing, electric ironing, laser, infrared rays, etc., to destroy the columnar epithelium on the erosive surface of the cervix, make it necrotic and fall off, and be covered by new squamous epithelium, but there are postoperative bleeding and infection. , long healing time, the possibility of infertility caused by cervical stenosis, and many adverse reactions to vaginal delivery, and it also brings a lot of inconvenience to patients' daily life

Method used

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  • Use of kerato cell growth factor-2 in treatment of chronic cervicitis medicine
  • Use of kerato cell growth factor-2 in treatment of chronic cervicitis medicine
  • Use of kerato cell growth factor-2 in treatment of chronic cervicitis medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Example 1: Recombinant human keratinocyte growth factor-2 or human keratinocyte growth factor-2 (KGF-2) was used to prepare vaginal suppositories for the treatment of chronic cervicitis. Formula: KGF-2 0.4g, glycerin 120g, gelatin 40g, mannitol 4g, phosphate 10g, human serum albumin 2g. Preparation method: Weigh 40g of prescription gelatin, add the same amount of pure water, soak for 1 hour, heat and dissolve in a water bath, then add 120g of glycerin, stir, evaporate the excess water to reduce the weight to 180g, add 4g of mannitol, human blood white 2g egg white, 10g phosphate, stir well, keep the temperature at 37℃-40℃, add 0.4g KGF-2, stir well, pour into the mold, cool naturally, cut off the overflow part of the mold mouth, demould, and seal.

Embodiment 2

[0018] Example 2: KGF-2 is used to prepare vaginal effervescent tablets for the treatment of chronic cervicitis. Formula: KGF-20.4g, glycerin 0.6g, citric acid 10g, sodium bicarbonate 8g, lactose 20g, PEG-6000 2g. Preparation method: Divide the lactose into two parts, mix one part with KGF-2, glycerol and citric acid, and the other part with sodium bicarbonate, respectively use 5% PVP anhydrous ethanol as a binder to granulate at 40℃ After drying, granulate, add PEG-6000, mix well, and press into tablets.

Embodiment 3

[0019] Example 3: KGF-2 is used to prepare vaginal gel for the treatment of chronic cervicitis. Formula: KGF-2 2g carbomer 940 12g, glycerin 50g, propylparaben 1g, triethanolamine 1.5g, pure water added to 1000g. Preparation method: take carbomer and sprinkle it into an appropriate amount of pure water, stir well to swell and disperse evenly, add KGF-2, glycerol and propyl p-hydroxybenzoate respectively, mix with carbomer solution and stir evenly, add triethanolamine Adjust the pH to a transparent and viscous state, and finally add pure water to a sufficient amount, and divide into packaging.

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Abstract

The invention discloses an application of keratinocyte growth factor-2 in the preparation of medicine for treating chronic cervicitis. The keratinocyte growth factor-2 is used as an active ingredient to prepare vaginal suppositories, vaginal effervescent tablets, vaginal gels and other vaginal administration dosage forms. The obtained medicine has good anti-inflammation effect on chronic cervicitis, promotes the repair of cervical epithelium, and has the advantages of simple operation, good effect and no toxic or side effect.

Description

technical field [0001] The invention relates to the use in the field of pharmacy, and more particularly to the use of a keratinocyte growth factor-2 (Keratinocyte growth factor-2, KGF-2) as a medicine for preparing a drug for treating chronic cervicitis. Background technique [0002] Keratinocyte growth factor-2 (Keratinocyte growth factor-2, KGF-2), also known as fibroblast growth factor-10 (fibroblast growth factor-10, FGF-10), is one of the members of the FGF family. It is secreted by fibroblasts and other mesenchymal cells, the specific target cells are various epithelial cells, and the specific receptors are tyrosine kinase receptors FGFR2 IIIb (KGFR) and FGFR1 IIIb, mainly responsible for mesenchymal cells - epithelial cells Signal transduction between and are cytokines that regulate mesenchymal-epithelial interactions. KGF-2 specifically promotes the proliferation, differentiation and migration of epithelial cells, and is an important multifunctional signaling molecu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61P15/00
Inventor 杨静尹龙武李颖夏雪雁彭仁琇敖英孔锐
Owner WUHAN UNIV
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