Purpose of a medicine composition in preparing medicament for enhancing effect of radiation therapy and chemotherapy

Abstract

The invention provides the application of a pharmaceutical composition in the preparation of a medicament for increasing the effect of radiotherapy and chemotherapy, the pharmaceutical composition comprising a therapeutically effective amount of a histone peracetylating agent and a pharmaceutically acceptable carrier or an effective amount of A pharmaceutically acceptable salt of a histone peracetylating agent; the use includes administering the pharmaceutical composition to an individual in need thereof. The preparation method of the pharmaceutical composition comprises the steps of taking the histone peracetylating agent and a pharmaceutically acceptable carrier, mixing them and heating them to form a paste, stirring and mixing, and then cooling. The compound simultaneously stimulates epithelial regeneration, inhibits fibroblast proliferation, reduces collagen deposition, inhibits fibroblast growth factors, reduces pro-inflammatory cytokines and regulates expression of cell cycle genes, tumor suppressors and oncogenes, and is useful for increasing radiation Therapeutic effect of therapy and chemotherapy and increased tumor growth inhibition and tumor therapeutic effect.

Description

technical field [0001] The present invention relates to the application of the pharmaceutical composition in the treatment of injury induced by chemotherapy and / or radiotherapy, more particularly, relates to the application of a pharmaceutical composition in the preparation of a medicament for increasing the therapeutic effect of radiotherapy and chemotherapy. Background technique [0002] Radiation therapy alone or concurrently or sequentially with chemotherapy is indicated for cancers of the head and neck, chest, skin, anogenital tract, and certain non-malignant diseases such as keloid, desmoid tumor, hemangioma ), arteriovenous malformation (arteriovenous malformation), and histocytosis X (histocytosis X) effective therapy. However, the therapeutic benefit is limited by the mucosal epithelial injury and epidermal radiation syndrome (CRS) induced by radiotherapy or chemotherapy, which include acute reactions such as tissue edema, mucositis, dermatitis, desquamation, etc. ...

AI Technical Summary

Problems solved by technology

[0008] However, in the current research results on histone deacetylation inhibitors, there is no detailed and reliable data on the use of this substance in the preparation of methods and pharmaceutical compositions for increasing the therapeutic effect of radiotherapy and chemotherapy, let alone the use of this substance. Experimental studies on methods and doses of formulations administered

It also lacks whether the active compounds of different structures in the histone deacetylation inhibitor have similar beneficial effects, etc., so that they cannot be widely and easily used by the society

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