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Fasciation naematoloma ligarine extraction, preparing method thereof and use in preparing pharmaceutical for treating tumour

A technology for extracting petroleum ether and tumor drugs, which is applied in the field of extraction and preparation of active ingredients of traditional Chinese medicine, and preparation of drugs for treating tumors. It can solve the problems of unseen extraction process and determination of pharmacological activity, and few researches on clustered umbrellas.

Inactive Publication Date: 2009-08-12
JILIN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After reviewing the domestic and foreign literature, there are few studies on the clustered algae, especially in the aspect of anti-tumor medicine, and there is no confirmation of its extraction process and pharmacological activity.

Method used

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  • Fasciation naematoloma ligarine extraction, preparing method thereof and use in preparing pharmaceutical for treating tumour
  • Fasciation naematoloma ligarine extraction, preparing method thereof and use in preparing pharmaceutical for treating tumour
  • Fasciation naematoloma ligarine extraction, preparing method thereof and use in preparing pharmaceutical for treating tumour

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Dry 1kg of the fruiting body of the fasciata fasciata at 40℃, crush it, and extract it with hot methanol at 50℃. The amount of methanol is 1.5 times the volume of the drug powder. The extraction is repeated twice, and 2500mL of the methanol extract is combined and concentrated to 250mL, then add 5 times distilled water to make a suspension, add 1 times the ratio of petroleum ether to extract three times, combine the petroleum ether extracts with 3500mL, concentrate, and evaporate the petroleum ether solvent in a water bath to obtain 4.3g petroleum ether extract. See the online analysis map of its temperament figure 1 .

Embodiment 2

[0085] 3.0 g of the petroleum ether extract of the clustered cylindracea obtained in Example 1 was applied to a silica gel column for separation. Among them, the silica gel column is 200-300 mesh silica gel, and the column is wet packed; the elution solvent is cyclohexane:ethyl acetate=7:5. The monomer compounds ergosterol peroxide 230mg and ergosterol 14mg can be obtained; the melting points are 177-179℃ and 152-155℃ respectively.

[0086] The obtained monomer compound ergosterol peroxide has a melting point of 177-179°C, white needle crystals; melting point: 178°C; solubility: easily soluble in petroleum ether, chloroform, ethyl acetate, acetone, slightly soluble in ethanol and methanol, Insoluble in water, positive reaction of acetic anhydride concentrated sulfuric acid, the spectrum is shown in the attachment Figure 2-9 .

[0087] The monomer compound ergosterol has a melting point of 152-155°C, white needle crystals; solubility: easily soluble in petroleum ether, chloroform,...

Embodiment 3

[0089] Dry 1 kg of the fruit body of A. chinensis at 30°C, crush it, extract with hot methanol at 60°C, extract three times with 2 times the amount of methanol, combine 3000 mL of methanol extract, concentrate 300 mL, and add 5 times distilled water to make a suspension Extract three times with 1 times the ratio of petroleum ether, combine 5000 mL of petroleum ether extract, concentrate, and evaporate the petroleum ether in a water bath to obtain 5.6 g of the petroleum ether extract of the clusters. See the online analysis map of its temperament figure 1 .

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Abstract

The invention discloses a petroleum ether extract of the chrysanthemum fruticosa, and at the same time, two monomer compounds of ergosterol peroxide and ergosterol are further separated. The invention also provides a preparation method for extracting the above-mentioned substances from the fruiting body and mycelia of the clustered mushroom, which is suitable for industrial production. Disclosed are the petroleum ether extracts of the chrysanthemum cymbidium, ergosterol peroxide and the use of ergosterol in treating tumor drugs.

Description

Technical field: [0001] The present invention discloses a cluster-growing parasol petroleum ether extract, and further separates two main monomer compounds ergosterol peroxide and ergosterol, and provides their use in the preparation of tumor treatment drugs, and belongs to the effective traditional Chinese medicine. Component extraction preparation method and medical application application technical field. Background technique: [0002] The Naematoloma fasciculare referred to in the present invention, also known as: clustered yellow mushroom, poisonous black umbrella, clustered yellow tough umbrella, has a bitter taste and is a poisonous mushroom that can kill people after eating. After consulting the domestic and foreign literature, there are few studies on the cluster-growing silk umbrella, especially in the anti-tumor medicinal application, and the extraction process and the determination of its pharmacological activity have not been provided. Summary of the invention: [0...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J71/00C07J9/00A61K31/58A61K31/575A61K36/07A61P35/00
Inventor 包海鹰丁燕图力古尔李玉
Owner JILIN AGRICULTURAL UNIV
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