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Temperature-sensistive chitosan/polyvinyl alcohol gel, and preparing method thereof

A polyvinyl alcohol gel, temperature-sensitive technology, used in the fields of drug sustained release, tissue engineering and cell culture, can solve the problems of slow response, limited application of hydrogel, poor mechanical properties, etc., to achieve good mechanical strength, High mechanical strength and good biocompatibility

Inactive Publication Date: 2009-07-08
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to some disadvantages of traditional hydrogels (such as poor mechanical properties, slow response speed, etc.), the application of hydrogels is greatly limited; therefore, in recent years, around improving the performance of hydrogels such as response speed and mechanical strength, research has been carried out. A wide range of research work

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1: 200mg chitosan is dissolved in the hydrochloric acid solution of 10ml0.1mol / l, after dissolving completely, stir in ice bath for 15min; 200mg polyvinyl alcohol is dissolved in the hot water of 80 ℃, is mixed with 2% (W / W) solution; sodium bicarbonate was dissolved in 1ml of distilled water to obtain 1mol / l sodium bicarbonate solution, added in polyvinyl alcohol solution, and placed in an ice bath for 15min; then, under constant stirring, poly The vinyl alcohol sodium bicarbonate solution was slowly dropped into the chitosan hydrochloric acid solution, and the solution was kept without turbidity, and stirred for 10 minutes. The solution was centrifuged for 3 min to remove air bubbles. Finally, the solution was placed at 21° C. for 30 min to form a gel. The gel temperature point can be obtained from a rheometer. When the gel is formed, there is no flow of liquid after inversion.

Embodiment 2

[0010] Embodiment 2: 200mg chitosan is dissolved in the hydrochloric acid solution of 10ml0.1mol / l, after dissolving completely, stir 25min in the ice bath; 500mg polyvinyl alcohol is dissolved in the hot water of 90 ℃, is mixed with 5% (W / W) solution; Dissolve sodium bicarbonate in 1ml of distilled water to obtain a 1mol / l sodium bicarbonate solution, add it to the polyvinyl alcohol solution, and place it in the ice bath for 25 minutes; then keep stirring in the ice bath , Slowly drop the polyvinyl alcohol sodium bicarbonate solution into the chitosan hydrochloric acid solution, keep the solution free of turbidity, and stir for 10 minutes. The solution was centrifuged for 3 min to remove air bubbles. Finally, the solution was placed at 26° C. for 30 min to form a gel.

Embodiment 3

[0011] Embodiment 3: 200mg chitosan is dissolved in 10ml0.2mol / l hydrochloric acid solution, after dissolving completely, stir 15min in ice bath; 1000mg polyvinyl alcohol is dissolved in the hot water of 85 ℃, is mixed with 10% ( W / W) solution; sodium bicarbonate was dissolved in 1ml of distilled water to obtain a 1mol / l sodium bicarbonate solution, added to the polyvinyl alcohol solution, and placed in an ice bath for 15min; then, under constant stirring, the polyethylene The alcoholic sodium bicarbonate solution was slowly dropped into the chitosan hydrochloric acid solution, keeping the solution free of turbidity, and stirring for 10 minutes. The solution was centrifuged for 3 min to remove air bubbles. Finally, the solution was placed at 34°C for 30 min to form a gel.

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Abstract

The invention discloses a temperature-sensitive chitosan / polyvinyl alcohol gel and a preparation method thereof. This chitosan / polyvinyl alcohol gel is a physical blend gel, and the effective components constituting the gel include chitosan and polyvinyl alcohol, and the gel temperature varies according to the proportioning ratio between chitosan and polyvinyl alcohol. different. Its preparation method is to dissolve chitosan completely in hydrochloric acid solution, and place it in an ice bath; add sodium bicarbonate solution to polyvinyl alcohol solution, and place it in an ice bath; Slowly drop the sodium bicarbonate polyvinyl alcohol solution into the chitosan hydrochloric acid solution to keep the solution free of turbidity, centrifuge to remove air bubbles, and place it at the gel temperature for a period of time to obtain a gel. This temperature-sensitive gel is liquid at low temperature and can form a gel at human body temperature. It can be used as an injection implant material. The preparation method is safe, simple and effective, and meets environmental protection requirements. It is suitable for the delivery of sensitive drugs. Release effect is good.

Description

technical field [0001] The invention relates to a temperature-sensitive chitosan / polyvinyl alcohol gel, which is suitable for the fields of drug sustained release, tissue engineering, cell culture and the like. Background technique [0002] Hydrogels have a hydrophilic three-dimensional polymer network structure that can absorb large amounts of water. The physical and chemical crosslinking between polymer chains can keep the hydrogel in a certain shape and not dissolve in water. Due to their good biocompatibility, hydrogels have been widely used in the field of biomedicine. Current research on hydrogels mainly focuses on the development and utilization of intelligent hydrogels. Smart hydrogels are a type of hydrogels that can respond sensitively to external stimuli, such as temperature, pH value, solvent, salt concentration, light, chemical substances, etc. According to the response to external stimuli, smart hydrogels can be divided into temperature-responsive hydrogels,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L29/04C08L5/08A61K47/32A61K47/36A61L27/52
Inventor 杜予民汤玉峰王小英
Owner WUHAN UNIV
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