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Spirulina composition as well as preparation method and application thereof

A technology of spirulina and composition, which is applied in the field of spirulina composition and its preparation, can solve the problems of components affecting the action of photosensitizers, low free radical generation efficiency, and insufficient detection, so as to improve optical sensitivity, biological Improved safety performance and good absorption effect

Active Publication Date: 2009-06-10
贵州圣济堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, it has been disclosed in the prior art that the C-phycocyanin contained in spirulina has certain photodynamic and photosensitive properties, but the free radical generation efficiency of this substance is low enough to be detected
And it is also pointed out in other literature that phycocyanin can enhance the function of the immune system. However, there is no precedent for using spirulina in combination with other photosensitizers in the prior art, and it is all due to the fact that the complexity of the ingredients may affect the photosensitizer. the role of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of spirulina composition when being used for photosensitizer

[0023] (a) Take 10-30 grams of spirulina, chlorin E 6 0.05-0.08 grams, 3-5 grams of zinc nitrate mixed;

[0024] (b) Add 1000mL deionized water and stir slowly until completely dissolved to prepare the photosensitizer of the spirulina composition.

Embodiment 2

[0025] Embodiment 2: the preparation of spirulina composition when being used for photosensitizer

[0026] (a) Take 20 grams of spirulina, chlorin E 6 0.07 grams, 4 grams of zinc nitrate mixed;

[0027] (b) Add 1000mL deionized water and stir slowly until completely dissolved to prepare the photosensitizer of the spirulina composition.

Embodiment 3

[0028] Example 3: Pharmacokinetics

[0029] Pharmacokinetic distribution in specific organs, tissues, body fluids and tumor tissue (embriocarcinome) for 30 hours. Test mice: Female BALB / c mice with a total weight of 20-21 grams were inoculated with T36 embryonic carcinoma on the hind leg muscles of these mice. After 2 weeks of inoculation of the tumor, the irradiation step was achieved by using diode laser ML-662-SP. Shave the skin of the irradiated area prior to proceeding. The study was performed on the basis of a Percin-elmer fluorescence spectrophotometer for intraperitoneal injection of organ and tumor tissues at a dose of 2.5 mg / kg (body weight).

[0030]Although given here are the experimental data and analysis results obtained by the spirulina composition of Example 2, those skilled in the art should understand that the larger range of spirulina compositions of Example 1 can obtain the same results.

[0031] The injection results are shown in Table 1, which shows tha...

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PUM

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Abstract

The invention relates to a spirulina composition photosensitizer, the preparation method and the application. The preparation method of the spirulina composition of the invention includes: spirulina, dihydroporphin E6 and zinc nitrate are mixed according to certain mixing ratio, 1000ml of deionized water is added for slow stirring till complete dissolution to prepare the invention. The obtained spirulina composition photosensitizer can be taken by oral administration or intravenous injection, does not cause the light sensitive problem of skin, and does not need to avoid light. In addition, the spirulina composition photosensitizer can carry out local treatment by activation by a laser light emitting instrument, at the same time, a light emitting tube array instrument (light bed) with small power is used for systemic therapy; compared with other photosensitizers, the spirulina composition photosensitizer is more practical and safe, and the overall performance is better than other photosensitizers.

Description

technical field [0001] The invention relates to the field of photon dynamic therapy, in particular to a spirulina composition that can be used as a photosensitizer, a preparation method and application thereof. Background technique [0002] Photodynamic therapy (PDT) is a promising cancer treatment that involves the use of visible light and photosensitizers. Photosensitizers are used therein as therapeutic agents. Each element of the photosensitizer is harmless, but when combined with oxygen, it produces a lethal cytotoxic factor, initially in the form of single-bonded oxygen, which prevents the development of tumor cells. The photosensitizer has higher selectivity for diseased tissue because only diseased cells that are simultaneously affected by the photosensitizer, photons and oxygen will be attacked by the cytotoxin. The dual selectivity of PDT therapy is reflected in the preferential uptake of photosensitizers by diseased tissues and the ability to make light act only...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/02A61P35/00A61K31/409A61K33/30
Inventor 丁林洪
Owner 贵州圣济堂制药有限公司
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