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Medicinal composition for treating chronic pelvic inflammatory disease, preparation method and quality control method therefor

A technology for chronic pelvic inflammatory disease and composition, which is applied in the field of pharmaceutical composition and its preparation method and quality control, can solve the problems of poor controllability of quality and curative effect, poor treatment pertinence of chronic pelvic inflammatory disease, complicated prescription and the like

Active Publication Date: 2008-03-26
庞来祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On February 3, 1999, the Chinese Patent Gazette published a patent application named "Angong Zhixue Granule" with a publication number of 1206611. , Shouwu, Polygala, Zaoren, Schisandra, Salvia, Radix Paeoniae Alba, Chuanxiong, Yuanhu, Angelica, Danpi, Bupleurum, Cundong, and Licorice, but the prescription is complicated, the quality and curative effect are poorly controllable, and it focuses on Supporting the spleen and strengthening the spleen, strengthening the skin and calming the nerves, nourishing qi and nourishing the essence, nourishing blood and regulating menstruation, mainly treating functional uterine bleeding, and the treatment of chronic pelvic inflammatory disease is not very specific
On December 24, 2004, the Chinese Patent Gazette published a patent application titled "Kangfuyan Tablets and Its Preparation Method" with a publication number of 1660187. Angelica, Chuanxiong, Rhizoma Cyperi, Corydalis Corydalis, Alisma, Hedyotis diffusa, although this tablet is also used to treat gynecological inflammation, it focuses on clearing away heat and detoxification, and is highly targeted in treating symptoms, and the root is insufficient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1 of the present invention: Astragalus 280g, Codonopsis 85g, Angelica 115g, Rhizoma Chuanxiong 70g, Curcuma 115g, Safflower 50g, Radix Paeoniae Rubra 115g, Cortex Moutan 50g, Peach Kernel 90g, Guizhi 50g.

[0064] Add 12 times the amount of water to five flavors of angelica, chuanxiong, zedoary, peony bark, and cassia twig, distill for 6 hours to extract the volatile oil, and collect the distilled aqueous solution in another device; add 12 times the amount of water to decoct the medicinal residues for 1 hour, filter the liquid for later use Add 12, 10, and 10 times the amount of water to decoct the remaining five flavors such as Astragalus membranaceus for three times, each time for 2 hours, combine the decoction, filter, merge the filtrate with the above liquid, and concentrate under reduced pressure (-0.08MPa) to a relative density of 1.10 ~1.12 (60°C), stand still for 24 hours, take the supernatant to recover ethanol and concentrate to a relative density of 1....

Embodiment 2

[0065] Example 2 of the present invention: Astragalus 170g, Codonopsis 140g, Angelica 50g, Chuanxiong 115g, Curcuma 50g, Safflower 90g, Radix Paeoniae Rubra 70g, Cortex Moutan 90g, Peach Kernel 50g, Guizhi 90g.

[0066] Angelica, Chuanxiong, Curcuma, Cortex Moutan, Guizhi Wuwei add 12 times the amount of water, distill for 6 hours to extract the volatile oil, and the distilled aqueous solution is collected in another device; the volatile oil is clathrated with 6 times the amount of β-cyclodextrin at 50°C for 2 hours. into clathrates. Add 12 times the amount of water to the medicinal dregs and decoct for 1 hour, and filter the liquid for later use; add 12, 10, and 10 times the amount of water to decoct the remaining five flavors such as astragalus for three times, each time for 2 hours, combine the decoction, filter, and the filtrate Combine with the above liquid, concentrate under reduced pressure (-0.08MPa) to a relative density of 1.10~1.12 (60°C), let it stand for 24 hours,...

Embodiment 3

[0067] Example 3 of the present invention: Astragalus 340g, Codonopsis 60g, Angelica 40g, Chuanxiong 45g, Curcuma 140g, Safflower 35g, Radix Paeoniae Rubra 140g, Cortex Moutan 35g, Peach Kernel 105g, Guizhi 35g.

[0068] Angelica, Chuanxiong, Curcuma, Cortex Moutan, Guizhi Wuwei add 12 times the amount of water, distill for 6 hours to extract the volatile oil, and the distilled aqueous solution is collected in another device; the volatile oil is clathrated with 6 times the amount of β-cyclodextrin at 50°C for 2 hours. Add 12 times the amount of water to decoct the dregs of the medicine for 1 hour, and filter the liquid for later use; add 12, 10, and 10 times the amount of water to decoct the remaining five flavors such as astragalus for three times, each time for 2 hours, and combine the decoction , filtered, the filtrate was combined with the above-mentioned medicinal solution, the combined solution was concentrated under reduced pressure to a medicinal solution with a relativ...

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Abstract

A Chinese medicine for treating chronic pelvic inflammation is prepared from 10 Chinese-medicinal materials including astragalus root, pilose asiabell root, Chinese agnelica root, Chuan-xiong rhizome, etc. Its quality control method includes such steps as thin-layer discrimination to Chuan-xiong rhizome, Chinese angelica root, tree peony bark, astragalus root and red peony root, and measuring the content of astragalus root.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its preparation method and quality control method, in particular to a pharmaceutical composition for treating chronic pelvic inflammatory disease and its preparation method and quality control method. Background technique [0002] Chronic pelvic inflammatory disease is one of the most common and frequently-occurring diseases in women. The main clinical manifestations are: dull pain in the lower abdomen and lumbosacral area, cold pain, warm and pressing, aggravated after exertion, dull tongue, thin white fur, deep thready pulse; Abdominal pain, lumps, dysmenorrhea, leukorrhagia and other disease categories, the result is a series of family and social problems such as long-term chronic pelvic pain, infertility or ectopic pregnancy. Most of the medicines currently used clinically to treat pelvic inflammatory disease are medicines for treating acute or subacute pelvic inflammatory disease. Western m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/73A61K36/71A61K36/54A61K36/481A61K36/344A61K36/286A61K36/236A61K36/232A61K9/00A61P15/00
Inventor 庞来祥
Owner 庞来祥
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