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Medicinal coating production for vascular stand and electrostatic spraying apparatus

A vascular stent and drug coating technology, applied in the field of medical devices, can solve the problems of loss of paint, low paint atomization rate, difficult gas pressure control, etc., and achieve the effects of improved utilization, uniform coating, and increased rate

Inactive Publication Date: 2008-03-12
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this traditional electrostatic spraying technology is that it is difficult to control the pressure of the gas, and it is inevitable to lose a large amount of paint in order to obtain a uniform coating on the surface of medical devices.
The disadvantages of this method are: ①The coating is purely electrostatically atomized, it is difficult to achieve complete atomization of the coating, and the atomization rate of the coating is low; ②Due to the electrostatic repulsion between the droplets, only a thin layer can be formed on the surface of the stent. layer, it is difficult to meet the requirements of the thickness of the drug coating; ③The formation of the coating depends entirely on electrostatic adsorption, and the speed at which the mist reaches the surface of the vascular stent is extremely slow, which reduces the efficiency of coating preparation

Method used

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  • Medicinal coating production for vascular stand and electrostatic spraying apparatus
  • Medicinal coating production for vascular stand and electrostatic spraying apparatus

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Experimental program
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Effect test

Embodiment 1

[0038] In order to meet the clinical needs of XX Hospital, and to prepare small-sized drug-coated vascular stents, the technical solution of the present invention is adopted, and the preparation steps are as follows: the first step is to place the vascular stents in acetone, ethanol and distilled water for ultrasonic vibration cleaning for 15 minutes , dried in a vacuum oven at 80°C for 20 minutes; the second step is to prepare the coating, the ratio of the drug to the polymer carrier is 1:1 (mass ratio), and the concentration of the polymer carrier in its solvent is 1%, wherein the drug Be paclitaxel, polymer carrier be poly(lactide-glycolide) and solvent be chloroform; The preparation of the 3rd step drug coating, high pressure pump pressure is 0.4MPa, the voltage of electrostatic generator is 1kv, nozzle and The distance between the stents is 1cm. After the coating is atomized, the charged droplets are deposited on the surface of the stent under the joint action of high-volt...

Embodiment 2

[0040] The drug-eluting vascular stents prepared in Dalian ×× Hospital for animal experiments are as follows: the first step is to select 32 316L stainless steel balloon-expandable vascular stents (3.0×20cm), and place the vascular stents in acetone , ethanol and distilled water for 20 minutes, and dried in a vacuum oven at 70°C for 25 minutes; the second step is to prepare the coating, the ratio of drug to polymer carrier is 1:10 (mass ratio), and the polymer carrier is in the The concentration in the solvent is 5%, wherein the drug is rapamycin, the polymer carrier is poly(lactide-glycolide) and the solvent is tetrahydrofuran; the preparation of the third step drug coating is divided into 32 vascular stents Two batches, one batch of 16, the distance between each vascular stent in each batch is 2cm, the pressure of the high-pressure pump is 1MPa, the voltage of the electrostatic generator is 25kv, the distance between the nozzle and the stent is 10cm, after the paint is atomiz...

Embodiment 3

[0042] For the treatment of peripheral vascular lesions, a NiTi shape memory alloy self-expanding vascular stent was selected, and a total of 10 preparation steps were as follows: the first step was to place the NiTi shape memory alloy self-expanding vascular stent in acetone, ethanol and distilled water for ultrasonic vibration cleaning for 20 minutes. , dry in a vacuum oven at 60°C for 30 minutes; the second step is to prepare the coating, the ratio of the drug to the polymer carrier is 1:100 (mass ratio), and the concentration of the polymer carrier in its solvent is 15%, wherein the drug It is rapamycin, the polymer carrier is polylactide and the solvent is methylene chloride; the preparation of the third step drug coating, 10 vascular stents are connected in series with a distance of 5cm, the pressure of the high-pressure pump is 7MPa, and the voltage of the electrostatic generator It is 60kv, and the distance between the nozzle and the bracket is 20cm. After the paint is ...

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Abstract

A process for preparing the coated medicine layer on the scaffold of blood vessel includes such steps as washing said scaffold, drying, proportionally mixing medicine with polymer carrier to obtain coating, connecting the scaffold to ground, high-pressure atomizing of said coating electrically charging the atomized coating by electrostatic generator, adsorbing the charged coating onto surface of scaffold under the action of electric field and high pressure, drying and disinfecting. Its electrostatic spray apparatus is composed of power source, changeover valve, high-pressure pump, coating container, filtering, electrostatic generator and spray gun with nozzle connected to said electrostatic generator.

Description

technical field [0001] The present invention relates to a drug coating preparation method for a vascular stent and an electrostatic spraying device thereof, more precisely, an efficient drug coating method for preparing a vascular stent by electrostatic spraying and an electrostatic spraying device thereof, belonging to medical devices field. Background technique [0002] In 1987, Sigwart (Sigwart U, et al. Intravascular stents to preventocclusion and restenosis after transluminal angioplasty. N Engl J Med, 1987, 316: 701) etc. implanted coronary stents into the human body for the first time, which provided a great deal for the treatment of coronary heart disease. good way. However, in-stent restenosis caused by vascular stent implantation largely limits its curative effect. The cause of restenosis is that blood vessels are damaged after being expanded by stents, which induces excessive proliferation of vascular smooth muscle cells and migrates to the intima, resulting in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/00A61F2/06A61L27/00A61L31/00B05D3/00B05B5/00
Inventor 齐民杨大智黄莹莹赵红邢滨刘洪泽
Owner DALIAN UNIV OF TECH
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