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Method for preparing astringent sponge of soluble cellulose

A technology of hemostatic sponge and cellulose, applied in medical science, bandages, absorbent pads, etc., can solve the problems of high cost, unsatisfactory hemostatic effect, inconvenient clinical use, etc., achieve low production cost, strong hemostatic effect, and reduce transmission risk effect

Inactive Publication Date: 2007-11-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing fibrous hemostatic product gelatin sponge still has high cost, unsatisfactory hemostatic effect and inconvenient clinical use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) It is 2: 1 by weight to take by weight the sodium carboxymethyl cellulose that the degree of substitution is 1.1 and the chitosan that the degree of deacetylation is 60%, it is 0.5% that the sodium carboxymethyl cellulose is mixed with distilled water The solution, chitosan is mixed with dilute acetic acid concentration and is a 1% solution, then the two solutions are mixed evenly;

[0019] (2) Add 10g / L polyethylene glycol 400, 2g / L sucrose, and 2g / L glycerin to the mixed solution obtained in step (1), and stir evenly, and let it stand for defoaming;

[0020] (3) Pour the mixed solution obtained in step (2) into a polystyrene container, and vacuum freeze-dry to obtain the sponge product of the present invention. The product is porous and relatively elastic, and the hemostasis time for rabbit ear veins is 55s, liver hemostasis time is 61s, and spleen hemostasis time is 68s.

Embodiment 2

[0022] (1) It is 6: 1 by weight to take the chitosan that the degree of substitution is 0.7 sodium carboxymethyl cellulose and the degree of deacetylation is 50%, and the sodium carboxymethyl cellulose is mixed with distilled water to have a concentration of 1%. The solution, chitosan is mixed with dilute acetic acid concentration and is 5% solution, then two kinds of solutions are mixed;

[0023] (2) Add 8g / L polyethylene glycol 400, 12g / L sucrose, and 2g / L glycerin to the mixed solution obtained in step (1), and stir evenly, and let it stand for defoaming;

[0024] (3) Pour the mixed solution obtained in step (2) into a polystyrene container, and vacuum freeze-dry to obtain the sponge product of the present invention. The product is porous and relatively elastic, and the hemostasis time for rabbit ear veins is 50s, liver hemostasis time is 58s, and spleen hemostasis time is 57s.

Embodiment 3

[0026] (1) It is 4: 1 by weight to take by weighing the sodium carboxymethyl cellulose that the degree of substitution is 0.9 and the chitosan that the degree of deacetylation is 95%, the sodium carboxymethyl cellulose is mixed with distilled water and is 1.5% concentration The solution, chitosan is mixed with dilute acetic acid concentration and is a 1% solution, then the two solutions are mixed evenly;

[0027] (2) Add 4g / L polyethylene glycol 400, 5g / L sucrose, and 1g / L glycerin to the mixed solution obtained in step (1), and stir evenly, and let it stand for defoaming;

[0028] (3) Pour the mixed solution obtained in step (2) into a polystyrene container, and vacuum freeze-dry to obtain the sponge product of the present invention. The product is porous and relatively elastic, and the hemostatic time for rabbit ear veins is 40s, liver hemostasis time is 51s, and spleen hemostasis time is 58s.

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Abstract

A staltic soluble cellulose sponge is proportionally prepared from carboxymethyl cellulose sodium and chitosan through dissolving carboxymethyl cellulose sodium in distilled water, dissolving chitosan in diluted acetic acid, mixing, adding polyethanediol 400, cane sugar and glycerin, stirring, laying aside while defoaming, filming, and vacuum freeze-drying.

Description

technical field [0001] The invention relates to a preparation method of a spongy material, in particular to a preparation method of a soluble cellulose hemostatic sponge. Background technique [0002] The rapid development of modern surgical medical technology has made great contributions to saving lives and healing the wounded. There are three major obstacles to the development of surgical operations, namely pain, wound infection, and bleeding. The problem of pain has been basically solved, and the continuous replacement of antibiotics has also basically solved the problem of wound infection. Bleeding has just become the biggest obstacle hindering the development of surgical operations. In surgical operations, whether the bleeding can be effectively stopped sometimes becomes the key to determine the success of the operation. At present, surgeons generally use ligation, suture ligation and electrocoagulation as methods for hemostasis and wound healing, but this method is n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/22
Inventor 何小维罗志刚
Owner SOUTH CHINA UNIV OF TECH
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