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Composite multi-layer dressing as well as preparation method and application thereof

A double-layer composite and polyvinyl alcohol technology, which is applied in dressings, non-adhesive dressings, coatings, etc., can solve the problems of cytotoxicity, removal of easy adhesions, adverse reactions of the human body, etc., and achieve the effect of improving performance

Pending Publication Date: 2022-03-25
XI'AN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medical dressings prepared on the market currently have problems such as single function, poor antibacterial effect, poor hemostatic effect, and easy adhesion during removal, which may cause secondary damage.
Even some antibacterial agents have potential cytotoxicity, cause adverse reactions to the human body, and have limitations in application. The use of traditional dressings has gradually failed to meet people's needs

Method used

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  • Composite multi-layer dressing as well as preparation method and application thereof
  • Composite multi-layer dressing as well as preparation method and application thereof
  • Composite multi-layer dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Dissolve an appropriate amount of chitosan powder in 1vol% acetic acid solution, stir at room temperature for about 12 hours, configure a chitosan solution with a mass fraction of 2%, and let it stand for degassing for 2 hours; take a certain amount of polyvinyl alcohol and dissolve it in In deionized water, heat and stir in a water bath at 60° C. for about 2 hours until the polyvinyl alcohol powder is completely dissolved to obtain a polyvinyl alcohol solution with a mass fraction of 8%. Mix the chitosan and polyvinyl alcohol solution at a ratio of 1:9, stir at room temperature for about 10 hours, and leave to defoam for 2 hours to obtain a transparent polyvinyl alcohol / chitosan spinning solution. Electrospinning was carried out in an environment with a temperature of about 25°C and a humidity of 35RH%. The spinning process parameters are as follows: the spinning voltage is 12KV, the liquid supply speed is 0.4mL / h, and the receiving distance is 12cm. The thickness of ...

Embodiment 2

[0043] Dissolve an appropriate amount of chitosan powder in 1vol% acetic acid solution, stir at room temperature for about 12 hours, configure a chitosan solution with a mass fraction of 3%, and let it stand for degassing for 2 hours; take a certain amount of polyvinyl alcohol and dissolve it in In deionized water, heat and stir in a water bath at 60° C. for about 2 hours until the polyvinyl alcohol powder is completely dissolved to obtain a polyvinyl alcohol solution with a mass fraction of 11%. Mix chitosan and polyvinyl alcohol solution at a ratio of 3:7, stir at room temperature for about 10 hours, and stand for defoaming for 4 hours to obtain a transparent polyvinyl alcohol / chitosan spinning solution. Electrospinning was carried out in an environment with a temperature of about 30°C and a humidity of 40RH%. The spinning process parameters are as follows: the spinning voltage is 16KV, the liquid supply speed is 0.8mL / h, and the receiving distance is 16cm. The thickness of...

Embodiment 3

[0048] Dissolve an appropriate amount of chitosan powder in 1vol% acetic acid solution, stir at room temperature for about 12 hours, configure a chitosan solution with a mass fraction of 4%, and let it stand for degassing for 2 hours; take a certain amount of polyvinyl alcohol and dissolve it in In deionized water, heat and stir in a water bath at 60° C. for about 2 hours until the polyvinyl alcohol powder is completely dissolved to obtain a polyvinyl alcohol solution with a mass fraction of 14%. Mix chitosan and polyvinyl alcohol solution at a ratio of 5:5, stir at room temperature for about 10 hours, and stand for defoaming for 4 hours to obtain a transparent polyvinyl alcohol / chitosan spinning solution. Electrospinning was carried out in an environment with a temperature of about 35°C and a humidity of 45RH%. The spinning process parameters are as follows: the spinning voltage is 20KV, the liquid supply speed is 1.0mL / h, and the receiving distance is 20cm. The thickness of...

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Abstract

The invention discloses a composite multilayer dressing as well as a preparation method and application thereof, and belongs to the technical field of medical dressings. The preparation method comprises the following steps: firstly, preparing a polyvinyl alcohol / chitosan nanofiber membrane through electrostatic spinning, and then continuously preparing an alginate / polyvinyl alcohol nanofiber membrane on the polyvinyl alcohol / chitosan nanofiber membrane through electrostatic spinning to obtain a double-layer composite nanofiber membrane; then carrying out crosslinking treatment on the double-layer composite nanofiber membrane to improve the performance; and finally, compounding with release paper and an isolating layer, and sterilizing to obtain the composite multi-layer dressing. The preparation method has the advantages of natural raw materials, simple operation and high production efficiency; the prepared composite multi-layer dressing has good biocompatibility, degradability and natural antibacterial property; as a medical dressing, other antibacterial agents do not need to be added, side effects on a human body are avoided, moisture absorption is good, removal is easy, secondary damage is reduced, and rapid healing and growth of a wound surface are facilitated.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to a composite multi-layer dressing and a preparation method and application thereof. Background technique [0002] With the in-depth study of the wound healing process, people's understanding of the pathophysiology of wound healing is becoming more and more profound. The medical dressings prepared on the market currently have problems such as single function, poor antibacterial effect, poor hemostatic effect, and easy adhesion during removal to cause secondary damage. Even some antibacterial agents have potential cytotoxicity, cause adverse reactions to the human body, and have limitations in application. The use of traditional dressings has gradually failed to meet people's needs. Contents of the invention [0003] In order to overcome the problems existing in the above-mentioned prior art, the object of the present invention is to provide a composite mult...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/22A61L15/44A61L15/46A61F13/00D01D5/00D01F8/10D01F8/18D04H1/4309D04H1/728
CPCA61F13/00987A61L15/225A61L15/44A61L15/46D04H1/728D04H1/4309D01D5/0084D01F8/18D01F8/10A61L2300/236A61L2300/402A61L2300/418A61L2300/404A61F13/01029
Inventor 魏亮段沐荣曾强张星曙周宇萌高旭文孙润军
Owner XI'AN POLYTECHNIC UNIVERSITY
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