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Zolmitriptan quick-release formulation

A technology for zolmitriptan and pharmaceutical preparations is applied in the field of pharmaceutical preparations to achieve the effects of improving the solubility of the main drug, high bioavailability and convenient taking

Active Publication Date: 2007-10-10
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] According to the characteristics of zolmitriptan, the present invention provides an immediate-release formulation of zolmitriptan, which can further improve the solubility of the main ingredient, that is, it can quickly form a uniform viscous suspension when it meets water, and can be used in the gastrointestinal tract. Rapidly disintegrates and disperses into fine particles, increases the distribution area of ​​the drug, increases the absorption points, greatly improves the speed of drug absorption in the gastrointestinal tract, and avoids the shortcomings of excessive drug concentration in the gastrointestinal tract and irritation of the gastrointestinal mucosa. Reduce adverse reactions, have the characteristics of convenient administration, fast absorption, high bioavailability, etc., and are convenient for patients to take

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] Embodiment (prescription quantity is 1000):

[0016] Eight specific prescriptions:

[0017] Prescription A:

[0018] Zolmitriptan 0.2g

[0019] Hydroxypropyl cellulose (disintegrant) 115.8g

[0020] Micronized silica gel (lubricant) 4g

[0021] Preparation process: the main drug is passed through a 100-mesh sieve, the disintegrant is passed through a 80-mesh sieve, the prescribed amount of the main drug and the disintegrant are weighed and mixed evenly, the prescribed amount of lubricant is added, mixed evenly, and tabletted to obtain the product. Dispersible tablet dispersion time limit is 1.0min.

[0022] Prescription B:

[0023] Zolmitriptan 0.6g

[0024] Hydroxypropylcellulose (disintegrant) 168g

[0025] 10% starch slurry (adhesive) 100g

[0026] Magnesium stearate (lubricant) 2g

[0027] Preparation process: The main drug is passed through a 100-mesh sieve, and the disintegrant is passed through a 80-mesh sieve. Weigh the prescribed amount of the main dru...

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PUM

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Abstract

The invention provides a Zolmitriptan quick-release formulation which can further improve the dissolving degree of the main medicament, greatly increase the absorbing velocity of the medicament in stomach and intestine, thus making the curative effect exert completely. Based on the physics and chemistry nature of the Zolmitriptan, adjuvant having specific disintegration and dissolving boosting actions for grease solving Zolmitriptan is selected from a plurality of medicinal findings through experiment.

Description

Technical field [0001] The invention belongs to the technology of pharmaceutical preparations. Background technique [0002] Migraine is one of clinical common disease, frequently-occurring disease, and its incidence rate is about 10%. The International Headache Society defines migraine as intermittent attacks of headache accompanied by autonomic disturbances. Clinically manifested as paroxysmal headache: often accompanied by dizziness, hearing loss and so on. The incidence of migraine in my country is 4.2% to 14.6%, and the male to female ratio is 1:4. With the acceleration of the pace of life and the increase of work pressure, the incidence of migraine in China is on the rise, and it has become a common and frequently-occurring disease that plagues people. A survey in China sampled 3377 people and found that 9.7% of them suffered from migraine. Epidemiological survey found that: about 6% of men and 17% of women suffer from migraine, and the most frequent age is 25 to 5...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/422A61K9/00A61P25/06
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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