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Composition for targeted cell treatment

a cell therapy and composition technology, applied in the field of chemotherapy and immunotherapy, can solve the problems of difficult development and among the most lethal of all cancers of pancreatic cancer

Inactive Publication Date: 2006-09-26
MARINKOVICH VINCENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0019]The invention is also directed to kits whose components are useful in cancer immunotherapy. The kits may include tran...

Problems solved by technology

For example, pancreatic cancers are among the most lethal of all cancers, because they grow rapidly, metastasize most often before the cancer is discovered, and are resistant to all known modes of therapy.
The initial enthusiasm for the use of monoclonal antibodies in treating cancer cooled when it became clear that an effective killer function was not easy to develop and that monoclonal antibodies needed further modifications to be effective at treating cancer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0092]Patient #1 was diagnosed to have a pancreatic cancer with metastases to the liver showing marked progression of hepatic metastases. The situation was said to be incurable and the treatment goals were palliative.

[0093]Computed Tomography (CT) scans of the upper abdomen showed numerous hypodensities scattered throughout all segments of both lobes of the liver of patient #1. All hypodensities measured less than 1 centimeter in diameter. There was a relatively hypodense and amorphous mass with ill-defined margins approximately 2×3×4 centimeters in the areas of the pancreas. The diagnosis at the time was inflammatory or neoplastic disease of the pancreas. The CT focused liver biopsy showed mild hepatic benign inflammatory disease. A repeat CT scan directed biopsy twenty days later showed clear islands of adenocarcinoma in the liver, thus confirming the pancreatic malignancy.

[0094]Chemotherapy was begun twenty-six days later and continued weekly for six cycles through one month. Aft...

example 2

[0102]The antigen Asp f1 was conjugated to the monoclonal antibody 17-1A (Panorex) from the National Cancer Institute. Panorex was chosen because it was commercially available and had monoclonal antibody activity against the pancreas. Once the Panorex and Asp f1 were combined, skin tests were performed on patient #1 with Panorex alone, Panorex plus Asp f1 and with Asp f1 alone. The patient showed a negative response to the monoclonal antibody, a strongly positive response to pure Asp f1 and an equally strong response to the Asp f1 conjugated monoclonal antibody at 48 and 72 hours.

[0103]The Asp f1 conjugate was administered to the patient following the standard protocol for the procedure for administration of the monoclonal antibody Herceptin available from Genentech. The procedure is as follows:

[0104]Dosage and Administration

[0105]The recommended initial loading dose is 4 mg / kg Asp f1 conjugate administered as a 90-minute infusion. The recommended weekly maintenance dose is 2 mg / kg ...

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Abstract

Compositions, vaccines and kits for cancer immunotherapy are described. The compositions, vaccines and kits may include transfer factor. The compositions, vaccines and kits also include modified monoclonal antibodies directed to cancer cells, other specific cancer receptor agonists, or viruses which infect cancer cells. The invention is also directed to methods of cancer immunotherapy using the compositions and vaccines of the invention.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This is an application claiming priority as a continuation-in-part to International application No. PCT / US99 / 15716, filed Jul. 12, 1999 designating the United States and claiming priority to U.S. Provisional Application No. 60 / 093,084, filed Jul. 16, 1998.FIELD OF THE INVENTION[0002]This invention relates to the field of therapeutic agents in medicine. In particular, this invention relates to the field of cancer immunotherapy.BACKGROUND OF THE INVENTION[0003]It is generally believed that the emergence of cancer in an individual is the result of a confluence of factors: an inherited genetic weakness, an environmental insult such as radiation or a chemical injury, and the failure of that individual's immune system to respond to the emerging cancer. While significant progress has been made in cancer research, many forms of cancer still remain incurable. For example, pancreatic cancers are among the most lethal of all cancers, because they gr...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61M36/14A61K38/19
CPCA61K38/19A61K39/165A61K2039/6056C12N2760/18734A61K2039/55516A61K2039/585A61K2300/00A61K39/12
Inventor MARINKOVICH, VINCENT
Owner MARINKOVICH VINCENT
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