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Integrated automatic blood processing unit

a blood processing unit and automatic technology, applied in the field of automatic processing, can solve the problems of affecting the efficiency of blood processing, and consuming a lot of resources, and achieve the effect of enhancing the function and increasing the efficiency of the system

Inactive Publication Date: 2006-05-02
ZENON TECH PARTNERSHIP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The present invention includes a console or electromechanical instrument that may be used to perform several different blood processing procedures. The console is a small, compact apparatus that has the various actuation pumps, valves, pressure-sensing transducers, ultrasonic detectors and other devices needed to implement the process using a closed, sterile disposable set. The invention further includes different disposable sets for each process that is specifically designed to implement that process and to contain all associated blood and fluids. As many functions and devices as possible are placed in the console, allowing simplification and reduction in size of the disposable set.
[0011]The console uses microprocessor-based electronics and software to select and control a variety of different processes. The console may identify the cassette installed in it by reading a bar code on the cassette. The microprocessor may then initiate the process appropriate for that cassette, with user verification. Automated data collection by the console plus bar code scanning by the user eliminates manual entries and allows error-free data to be provided to a blood center computer.
[0012]Other features of the invention include a low-cost manifold as part of the disposable set that contains the actuation and sensing components, and a simple, low-cost, continuous-flow centrifuge assembly with unique features that increase its efficiency. Additionally, in particular embodiments of the present invention, additional components such as optical sensors, a free plasma hemoglobin sensor and a recirculation bag shaker may be included to implement or enhance the function of the present invention.

Problems solved by technology

Conventional, disposable autotransfusion sets are also quite expensive, since most current systems use batch processing of blood in relatively large centrifuge bowls.
System set-up is also burdensome, and takes about five minutes.
A technician operates the system for vascular surgery or orthopedic surgery, also adding to the cost of the procedure.
Such an apparatus may allow a nurse or anesthesiologist to set up and monitor the system operation during use, saving substantial time and cost.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Automatic Glycerolization of Standard Unit of Packed RBCs in Storage Solution

[0159]Red cells are collected from a donor in a standard bag with a standard anticoagulant. They are concentrated by standard methods to a hematocrit of about 90% and storage solution is added. This bag of a standard packed RBC blood component is then attached with a sterile docking device to the sterile disposable set, using a cassette configured for a glycerolization process that interacts with the control module. Glycerol solution is in a bottle attached to the disposable set using a standard spike; although it will be readily apparent to one of skill in the art that solutions other than glycerol may be used in accordance with this embodiment of the present invention. Sterility is achieved by using a bacterial filter for glycerol added to the RBCs. Glycerol solution is slowly added based on RBC volume. Then, the RBCs are concentrated, by removing fluid, to a hematocrit of about 75% to 80%. Glycerolized R...

example 2

Automatic Deglycerolization of RBCs

[0170]The system of the present invention may be used to automatically deglycerolize (i.e., RBC washing and removal of glycerol and free plasma hemoglobin) a unit of glycerolized, frozen and then thawed RBCs; although it will be readily apparent to one of skill in the art that solutions other than glycerol may be removed in accordance with this embodiment of the present invention. The overall approach for deglycerolization is to mix the glycerolized RBCs first with a hypertonic solution that shrinks the RBCs and expels some of the glycerol from the RBCs. Then, the RBCs are washed in an isotonic solution to remove glycerol and free plasma hemoglobin from the fluid surrounding the RBCs. During this wash process, glycerol diffuses out of the cells and the RBCs return to normal volume.

[0171]As illustratively depicted in FIG. 53, the present invention may be configured as a system 5300 to perform an automatic deglycerolization process. In this configura...

example 3

Alternative Solutions for Use in Deglycerolization Processes

[0194]The current storage solutions generally contain both glucose and electrolytes such as sodium phosphate, sodium citrate and sodium chloride. They are prepared at pH 5.7 or thereabouts since autoclaving to sterilize the solutions causes caramelization of the glucose when both glucose and salts are present at a pH much above 6.2. The principal requirements for storage of RBCs after deglycerolization are hemolysis less than 1% and survival of transfused RBCs above 75% after 24 hours in human volunteers.

[0195]In order to obtain good refrigerated cell storage, the cells must be able to maintain metabolic processes. The presence of certain metabolites, such as glucose, phosphate and adenine has been shown to achieve this, but for maximum benefit, the pH should be in the physiological range of 7.0 or higher. Alkaline pH is not currently used in RBC storage solutions because of the obstacle of sterilization by heat, which at h...

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Abstract

A system for automatically processing blood components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of priority under 35 U.S.C. § 119 of provisional U.S. patent application Ser. No. 60 / 374,141, filed Apr. 19, 2002, entitled “Integrated Blood Collection and Processing Unit,” the contents of which are hereby incorporated by reference in their entirety. This application also claims the benefit of priority under 35 U.S.C. § 120 as a continuation-in-part of U.S. patent application Ser. No. 10 / 179,920, filed Jun. 24, 2002, entitled “Integrated Automatic Blood Collection and Processing Unit,” the contents of which are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION[0002]This invention relates generally to devices and methods for the automated processing of blood or blood components already collected from a donor or patient.BACKGROUND OF THE INVENTION[0003]Conventional methods and equipment for preserving red blood cells (RBCs) in the frozen state have been available for many years. The U.S. military h...

Claims

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Application Information

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IPC IPC(8): B01D21/26A61M1/36B01D17/02B04B5/04
CPCA61M1/3693A61M2205/12B01D17/0217B04B5/0442A61M1/3633A61M1/0218A61M1/3692A61M1/3696A61M1/362227A61M1/362265A61M1/36226A61M1/36224A61M1/362261
Inventor ROBINSON, THOMAS C.ROBINSON, THOMAS P.D'ELIA, RICHARDEIBE, PAULSAHINES, THOMAS
Owner ZENON TECH PARTNERSHIP
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