New use of angiotensin ii type 2 receptor agonist

Abstract

There is provided N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-isobutylthiophene-2-sulfonamide, or a pharmaceutically-acceptable salt thereof, for use in a method of treatment of respiratory virus-induced tissue damage. Such damage may be caused by coronaviruses, including severe acute respiratory syndrome coronavirus and severe acute respiratory syndrome coronavirus. N-Butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide alleviate symptoms of diseases caused by those viruses (including coronavirus disease 2019 or COVID-19), such as cough, dyspnea, pneumonia, respiratory distress, respiratory failure and / or fibrosis of organs such as the lungs, the heart or the kidneys, and may thus prevent respiratory virus-induced morbidity and / or mortality. In particular, it has been found in a clinical study that the proportion of patients with COVID-19 needing oxygen treatment was significantly lower for patients that were administered N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide compared to placebo.

Description

[0001]This application claims the priority benefit of GB 2004209.9, filed Mar. 23, 2020, and GB 2009574.1, filed Jun. 23, 2020.FIELD OF THE INVENTION[0002]This invention relates to the new use of a known compound.BACKGROUND AND PRIOR ART[0003]A virus is a very small organism comprising genetic material (DNA or RNA) that is capable of infecting a biological organism. A virus invades and attaches itself to a living cell, after which it multiplies to produce more virus particles (virions), which attach to and enter susceptible cells.[0004]A virus may either kill a cell or alter its functions leading to the infection of other cells. This will then generally lead to what is termed as a viral disease (or a viral infection).[0005]In general, viruses only infect one type of cell, but can be transmitted in various ways, including contact with infected individuals or their bodily secretions, animals (such as arthropods), or inanimate objects. Viruses can also be transmitted by inhalation or s...

AI Technical Summary

Benefits of technology

The invention provides a method for treating respiratory virus-induced tissue damage by administering C21 or a pharmaceutically-acceptable salt thereof to a subject in need of such treatment. C21 can prevent and treat damage caused by respiratory viruses, including influenza viruses and coronaviruses such as SARS-CoV. The treatment can be therapeutic, symptomatic, and palliative, and can also prevent and mitigate the development of diseases associated with respiratory virus infections. The invention also provides pharmaceutically-acceptable salts of C21 and precursors of C21 that can be administered to a subject. The method can be used on avian and mammalian subjects, including humans, and different dosages can be given based on the age of the patient.

Problems solved by technology

The immune response can often lead a patient feeling unwell or fatigued.

If a patient's immune system is compromised, or not effective enough to prevent the spread of a virus, this can lead to severe illness and, in some instances, morbidity and / or death.

Indeed, there are many different types of viruses that can seriously affect lung function and cause respiratory illnesses.

Moreover, C21 has been found not to improve pulmonary gas exchange or have other relevant beneficial clinical effects in a model of acute lung injury (Menk et al, J. Inflamm. Res., 11, 169 (2018)).