Cereblon ligands and bifunctional compounds comprising the same
a technology of ligands and e3 ligases, applied in the field ofimide-based compounds, can solve the problems of difficult development of ligands of e3 ligases, difficult targeting of protein-protein interactions using small molecules, and encouraging the effect of brd4 inhibition
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[1602]ACN: acetonitrile[1603]ADDP: 1,1′-(azodicarbonyl)dipiperidine[1604]BAST: N,N-bis(2-methoxyethyl)aminosulfur trifluoride[1605]BPO: benzoyl peroxide[1606]Cbz: Carbonylbezyloxy[1607]DAST: diethylaminosulfur trifluoride[1608]DBE: 1,2-dibromoethane[1609]DCM: dichloromethane[1610]DEAD: diethyl azodicarboxylate[1611]DIAD: diisopropyl azodicarboxylate[1612]DIBAL: disiobutylaluminium hydride[1613]DIEA or DIPEA: diisopropylethylamine[1614]DMA: N,N-dimethylacetamide[1615]DMF: N,N-dimethylformamide[1616]DMP: Dess-Martin periodinane[1617]EA: ethyl acetate[1618]EDCI: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide[1619]HBTU: N,N,N′N′-tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate[1620]HMDS: bis9trimethylsilyl)amine[1621]HMPA: hexamethylphosphoramide[1622]LDA: lithium diisopropylamide[1623]MCPBA: meta-chloroperoxybenzoic acid[1624]MsCl: methanesulfonyl chloride[1625]M.W: microwave[1626]NBS: N-bromosuccinimide[1627]NMP: N-methylpyrrolidone[1628]PCC: pyridinium chlo...
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