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Gel-Based Compositions and Methods of Use

a composition and gel technology, applied in the field of oral or dental and topical or dermal pharmaceutical compositions or formulations, can solve the problems of chlorhexidine but is still undetectedly toxic for prolonged use in patients, adverse effects in the oral cavity and/or system, and poor oral hygiene, so as to prevent the formation of biofilms, improve the hemostasis of injury, and reduce dental caries

Inactive Publication Date: 2016-07-21
RODRIGUEZ ARCADIO MALDONADO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]The present invention is directed further still to a method for reducing dental caries in a subject. The method comprises applying an amount of the oral gel composition described herein to teeth and gums of the subject effective to prevent the formation of biofilms thereon.
[0014]The present invention is directed further still to a method for treating an injury to skin on a subject. The method comprises applying an amount of the topical gel composition described herein to the injury thereby improving hemostasis of the injury and increasing analgesia in the subject.

Problems solved by technology

Another risk factor is poor oral hygiene.
While current products can provide a temporary antiseptic protective effect, adverse effects in the oral cavity and / or systemically can result.
Similarly, the antiseptic Triclosan is less toxic than chlorhexidine but is still undesirably toxic for prolonged use in patients.
Dental caries is still a problem in developed countries affecting between 60% and 90% of the school population and the vast majority of adults.
The genesis of dental biofilm is a dynamic and complex process and is difficult to understand in its entirety.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of Oral Gel Composition

[0036]To create one preferred formulation of the dental gel composition, to 7.5 liters of ozonized water at <20 ppb (<20 μg / l), 300 g of carbopol #940 is added. The carbopol-ozonized water is homogenized and allowed to stand for about 24 hours. Subsequently, the formulation is polymerized with 38 ml of sodium hydroxide (NaOH / 5%), 20 ml of glycerol, 22.5 ml of acetic acid, 375.0 g of trichloro-galactosucrose, 7.5 g of methyl paraben and 37.5 ml of mint. 30 grams or 1 oz of oral gel composition is produced.

[0037]Thus, a preferred formulation of the oral gel composition of the present invention is: 1) ozonized water; 2) carbopol #940; 3) sodium hydroxide (NaOH); 4) glycerol; 5) acetic acid; 6) trichloro-galactosucrose; 7) methyl paraben; and 8) mint.

example 2

Study Design and Methodology

[0038]An intervention study of minimal risk to the health of the participating subjects was undertaken with a duration of 168 days (24 weeks), nominal data and scale-up of 3 cohorts or groups made up of ten subjects each, 1) Study Group, 2) Control 1 Group and, 3) Control 2 Group. This study was designed to show whether the use of the oral dental gel composition applied to dental organs of the participating study group was able to prevent the development of plaque and tartar dentomicrobiana compared to the development of plaque and tartar on dentomicrobiana groups Control 1 Group and Control 2 Group. To this end, 30 subjects of either sex and any age as a “healthy” population were enlisted (15 from the city of Colima and 15 from the city, Uriangato, Guanajuato) were informed of the minimum risk to subjects and of potential participation during follow-up in the event of conditions that endanger the health of the subject. The subjects read and signed the in...

example 3

Preparation of Derma Gel Skin

[0053]To create a formulation of the topical gel composition or derma gel, to 15 liters of ozonized water at <20 ppb (<20 pg / I), 105 g of carbopol #940 is added. The carbopol ozonized water is homogenized and allowed to stand for about 24 hours. Subsequently, the solution is polymerized with 50 ml of sodium hydroxide (NaOH / 5%), mixed, and 30 ml acetic acid, 30 ml of 3% hydrogen peroxide and 15 g of methyl paraben are added to arrive at the final formulation. About 60 g or 2 oz are produced.

[0054]Thus, a preferred formulation of the topical or dermal gel composition of the present invention is: 1) ozonized water; 2) carbopol #940; 3) sodium hydroxide (NaOH); 4) acetic acid; 5) hydrogen peroxide; and 6) methyl paraben.

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PUM

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Abstract

Provided herein are a biocompatible gels such as an oral gel composition. Generally, the oral gel composition may comprise a formulation in ozonized water of a cross-linked polyacrylate polymer and a preservative and sodium hydroxide, acetic acid, and glycerol to polymerize the polyacrylate. Optionally, the oral gel composition may comprise a sweetener and / or a flavoring agent. The topical gel composition is a similar formulation in ozonized water with a cross-linked polyacrylate polymer and a preservative and sodium hydroxide, acetic acid, and hydrogen peroxide to polymerize the polyacrylate. Further provided is a method of using the gel compositions to reduce dental caries.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a divisional of pending application U.S. Ser. No. 14 / 576,290, filed Dec. 19, 2014, the entirety of which is hereby incorporated by reference.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates generally to the fields of oral and topical pharmaceutical compositions or formulations. More specifically, the present invention relates to gel based oral or dental and topical or dermal pharmaceutical compositions and formulations and methods for their use.[0004]2. Description of the Related Art[0005]Oral health can be defined as the absence of acute or chronic orofacial pain, oral and throat cancer, oral sores, birth defects such as cleft lip or palate defects, periodontal disease, tooth decay, tooth loss, and other diseases and disorders that affect mouth. Oral diseases share risk factors with the four major chronic diseases that affect humans (cardiovascular diseases, cancer, chronic...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/04A61K8/37A61Q11/00A61K8/36A61K8/34A61K8/19A61K8/81A61K8/60
CPCA61K8/042A61K8/8152A61K8/37A61Q11/00A61K8/36A61K8/345A61K8/19A61K8/60A61K9/0063A61K47/32A61K33/40A61K31/78A61K9/0014A61P1/02A61P17/02A61K2800/70
Inventor RODRIGUEZ, ARCADIO MALDONADO
Owner RODRIGUEZ ARCADIO MALDONADO
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