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Compositions and kits for treating pruritus and methods of using the same

a technology for pruritus and preparations, applied in the field of treatment, amelioration, and prevention of pruritus, can solve the problems of skin irritation, infection, bleeding and infection, wound healing after injury or surgery is often accompanied by localized itching, and antihistamines are not effective in some forms, so as to reduce local inflammation, promote healing, and control odor

Inactive Publication Date: 2016-04-14
ROCHAL TECH LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a treatment for pruritus (skin itching) that uses amylase, an enzyme that breaks down starch. Amylase is stable in water and can be easily removed from the skin, making it suitable for use in a hydrophilic formulation. The formulation also contains a polymer that increases its viscosity, making it more effective at treating pruritus. This treatment method can help reduce the symptoms of pruritus and provide a more comfortable experience for patients.

Problems solved by technology

Scratching can be severe, resulting in irritation and inflammation of the skin, as well as bleeding and infection.
Wound healing after injury or surgery is often accompanied by localized itching.
Other substances act independently; therefore, antihistamines are not effective in some forms of pruritus.

Method used

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  • Compositions and kits for treating pruritus and methods of using the same
  • Compositions and kits for treating pruritus and methods of using the same

Examples

Experimental program
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Effect test

example 1

[0154]A male Caucasian septuagenarian applied bacterial α-amylase #6 solution to his skin damaged by pruritus, which resulted in inflamed red welts caused by scratching. The α-amylase solution was adjusted to pH 7 by NaOH, at a ratio of water / amylase of 99.6610.34 by weight, wherein the α-amylase activity was 1 g / 25,000 U. The solution was wiped onto inflamed, pruritic skin containing red welts using a non-woven cloth treated with the enzyme formulation. The solution was left on the skin for 10 minutes, with no observable discomfort, and removed by wiping several times with a wet cloth. The pruritus was reduced approximately 15 minutes after initial application, and the skin remained in a less inflamed state for at least 12 hours. The process was repeated every 12 hours for two days with elimination of pruritus and marked reduction and elimination of red welts.

example 2

[0155]On another area of pruritic skin with irritation and inflammation, the above mentioned male utilized an antimicrobial amylase formulation based upon 25 mg of porcine pancreatic α-amylase #3 mixed in 21 g of PHMB-based Antimicrobial Composition (AC), prepared in 4 glass vials containing 5.0 ml amylase / AC per vial. Over a period of 48 hours, the content of each of the 4 vials were applied on a non-woven fabric every 12 hours to cleansed pruritic skin. Itching was abated during the first treatment, and irritation and inflammation greatly reduced after 48 hours.

example 3

[0156]A 70 year old Caucasian female was bitten by mosquitoes over a two day period. The first area affected was untreated and resulted in a red, itchy bump of approximately one-quarter inch in diameter by day 2. On the second day, another mosquito bite occurred, becoming rapidly itchy. The second bite was as pruritic as the first bite and a powder of bacterial α-amylase #6 was applied directly to both affected areas (i.e., the first and second bites). The first bitten area had a decreased redness and decreased irritation after 15 minutes of treatment, whereas the second bitten area had decreased redness and elimination of pruritus with no red bump occurring.

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Abstract

A treatment for pruritus is described that is based upon amylase. The amylases (α-, β-, γ-amylase) are noted for the cleavage of the α-glycosidic bonds of polysaccharides, yielding lower molecular weight carbohydrate / sugar fragments. It has now been found that α-amylase is effective in the reduction of pruritus (itching) of affected tissue.

Description

FIELD OF THE INVENTION[0001]This invention relates generally to the treatment, amelioration, and prevention of pruritus and its potential concomitant irritation and inflammation in humans and animals using α-amylase and formulations thereof.BACKGROUND OF THE INVENTION[0002]Pruritus is a condition that involves localized or general itching, which often leads to the urge to scratch and the stimulation of sensory nerve endings. Scratching can be severe, resulting in irritation and inflammation of the skin, as well as bleeding and infection. Although pruritus usually occurs in the skin, it can also occur in non-cutaneous sites, such as mucous membranes or the cornea. A variety of causes of pruritus are recognized, including external and exogenous effects, localized skin disorders, and systemic diseases. Wound healing after injury or surgery is often accompanied by localized itching. Pruritus can also be a component of inflammation.[0003]Histamine is one of the most important mediators o...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/54
CPCA61K38/54C12Y302/01003C12Y302/01002C12Y302/01001C12Y304/24003C12Y301/01003A61K9/08A61K38/47A61K9/0014A61K31/785A61K9/1075A61K47/38A61K47/18A61K47/24A61K38/465A61K47/10C12Y301/01A61P17/04A61P25/00A61P43/00A61K2300/00A61K9/7007A61K47/02A61K47/06A61K31/155
Inventor SALAMONE, JOSEPH CHARLESSALAMONE, ANN BEALLEUNG, KELLY XIAOYU CHENREILLY, KATELYN ELIZABETH
Owner ROCHAL TECH LLC
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