Composition comprising the extract of herbal combination for preventing or treating diabetic peripheral neuropathy

Abstract

Disclosed are a pharmaceutical composition and a health functional food for the prevention and treatment of diabetic peripheral neuropathy, comprising an herb extract of a mixture of 3.5:1 Dioscorea Rhizoma:Dioscorea nipponica (w / w). Having the ability to synergistically increase in vivo levels of nerve growth factor, compared to the extracts from the herbs alone or herb mixtures of other weight ratios, the mixed herb extract is effective for preventing the apoptosis of nerve cells and promoting nerve regeneration. Thus, it can be applied to pharmaceutical compositions and health functional foods preventive and curative of diabetic peripheral neuropathy.

Description

TECHNICAL FIELD[0001]The present invention relates to a composition for the prophylaxis and therapy of diabetic peripheral neuropathy, comprising a herbal extract of a mixture of 3.5:1 Dioscorea Rhizoma:Dioscorea nipponica (w / w).ACKNOWLEDGEMENT[0002]This work was supported by the Global Leading Technology Program of the Office of Strategic R&D Planning (OSP) funded by the Ministry of Knowledge Economy, Republic of Korea. (No. 10039303)BACKGROUND ART[0003]The incidence of diabetes mellitus is rapidly increasing worldwide. The World Health Organization estimated that approximately 180 million people are suffering from diabetes mellitus as of 2008, with the prospect of the number of diabetics doubling by 2030. Accordingly, the financial and social costs associated with diabetes have risen, and there has been an increase in mortality from the complications of diabetes. However, the onset or progression of diabetes can be retarded by strict management of the blood sugar level, so that it...

AI Technical Summary

Benefits of technology

The herb extract described in this patent is a mixture of two plants, Diosorea Rhizoma and Diosorea nipponica, and has been found to have significantly better effects on increasing the levels of nerve growth factor, promoting the growth of nerves, and improving cognitive ability compared to extracts from either plant alone or other mixtures. This makes it useful for creating pharmaceutical compositions and health functional foods to prevent and treat diabetic peripheral neuropathy.

Problems solved by technology

Accordingly, the financial and social costs associated with diabetes have risen, and there has been an increase in mortality from the complications of diabetes.

It is the most common complication that diabetics encounter.

Diabetic peripheral neuropathy deteriorates the quality of life of diabetes patients and is the greatest source of patient mortality.

The pain may worsen and become incurable.

However, the development of most of them was stopped halfway due to side effects and insufficient efficacy.

However, it is difficult to find therapies that adequately treat patients with diabetic peripheral neuropathy because there is a high versatility of etiologies and symptoms.

However, a randomized placebo-controlled, phase 3 clinical trial was conducted over 48 weeks yet was not significantly effective due to pain at the injection site and insignificant pharmaceutical effects.

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