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Synergism of gos and polyfructose

a technology of gos and polyfructose, which is applied in the field of human health and nutrition, can solve the problems of unwanted symptoms, flatulence and abdominal pain, and range of undesirable effects, and achieve the effects of improving the quality of life, reducing the risk of side effects, and improving the effect of glucose absorption

Inactive Publication Date: 2013-08-15
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about the use of a mixture of GOS and polyfructose to improve the colonic environment of infants. When administered together, this mixture has been found to increase the production of beneficial fermentation products, including lactate, while decreasing the amount of harmful products like butyrate. This results in a more desirable fermentation pattern, similar to the one in breast fed infants. The use of lactate, in particular, was found to increase the secretion of prostaglandin E1 and prostaglandin E2, which are important for maintaining a healthy colon. The use of these mixtures can therefore help to improve colon health and relieve pain and discomfort.

Problems solved by technology

But also the formation of gases, which results in unwanted symptoms such as flatulence and abdominal pain, has been reported when introducing prebiotics, such as inulin or GOS, into the diet.
Furthermore, not only acetate but also increases in, for example, butyrate have been reported, which is undesirable.
A range of undesirable effects have therefore been described, resulting from the consumption of nutrition supplemented with certain prebiotics.

Method used

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  • Synergism of gos and polyfructose
  • Synergism of gos and polyfructose
  • Synergism of gos and polyfructose

Examples

Experimental program
Comparison scheme
Effect test

example 1

In Vitro Fermentation Studies Show Synergistic Effects on Fermentation Patterns

1.1 Materials and Methods

Microorganisms

[0106]Microorganisms were obtained from fresh faeces from bottle fed babies. Fresh faecal material from babies ranging 1 to 4 month of age was pooled and put into preservative medium within 2 h.

Compositions / Substrate

[0107]As substrate either prebiotics (TOS; TOS (from VivinalGOS, Borculo Domo Ingredients, The Netherlands) and inulin (raftilinHP from Orafti, Belgium) mixture in a 9 / 1 (w / w) ratio; inulin; oligofructose and inulin mixture in a 1 / 1 (w / w) ratio, or none (blanc) was used.

Media

[0108]McBain & MacFarlane medium: Buffered peptone water 3.0 g / l, yeast extract 2.5 g / l. mucin (brush borders) 0.8 g / l, tryptone 3.0 g / l, L-Cysteine-HCl 0.4 g / l, bile salts 0.05 g / l, K2HPO4.3H2O 2.6 g / l, NaHCO3 0.2 g / l, NaCl 4.5 g / l, MgSO4.7H2O 0.5 g / l, CaCl2 0.228 g / l, FeSO4.7H2O 0.005 g / l. 500 ml Scott bottles were filled with the medium and sterilised for 15 minutes at 121° C.

[0109...

example 2

Clinical Study with TOS / Inulin: a Relative Increase of Acetate and Relative Decrease of Butyrate is not Correlated with an Increase of Bifidobacteria. TOS and Inulin have a Synergistic Effect

2.1 Materials and Methods

[0127]63 pregnant woman who had decided to breast-feed and 57 who chose not to, were recruited during their last trimester of pregnancy. Infants with normal birth weight, no congenital abnormality, congenital disease or gastrointestinal disease were enrolled within 3 days after delivery. The study was approved by the ethical committee of the Medical Center, St. Radboud, Nijmegen, The Netherlands. Written informed consent was obtained from the parents before enrolment in the study.

[0128]Infants of mothers who had decided not to breast-feed, were randomly and double blindly allocated to one of two formula groups (OSF, SF). The standard formula group (SF; n=19 received a regular, non-supplemented infant formula (Nutrilon I, Nutricia, The Netherlands). The main compositional...

example 3

Beneficial Effects of Lactate and SCFA Mixture on Muc-2, PGE1 and PGE2 Expression

3.1 Material and Methods

[0145]The effect of lactate and a SCFA mixture was analysed as described in Willemsen, L E M, Koetsier M A, van Deventer S J H, van Tol E A F (2003), Gut 52:1442-1447, with the following modifications: Lactate and a mixture of acetate / propionate / butyrate 90 / 5 / 5 was tested. For the mucus production experiments a co-culture of CCD18 and T84 cells was used, whereas for the PGE1 and PGE2 production experiments a monoculture of CCD18 cells was used.

3.2 Results

[0146]SCFA, in a mixture of 90 / 5 / 5 (acetate / propionate / butyrate), and L-lactate dose dependently induces MUC-2 expression in a co-culture of CCD18 and T84 cells as can be seen in FIG. 4A. Also the concentration of PGE1 and PGE2 increases in CCD18 cells as can be seen in FIG. 4B. At higher concentrations of the added organic acids the increases reaches statistically significance.

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Abstract

The present invention relates to the field of prebiotics. Provided are uses for compositions comprising synergistically effective amounts of polyfructose and galactooligosaccharides (GOS).

Description

FIELD OF THE INVENTION[0001]The present invention relates to the field of human health and nutrition. It provides novel synergistic mixtures of prebiotic carbohydrates, especially mixtures of galacto-oligosaccharides (GOS, for example TOS) and polyfructose (for example inulin), as well as nutritional compositions comprising these. The nutritional compositions have beneficial effects when fed to bottle fed or partially bottle fed infants and also have health improving effects when ingested by adults having intestinal problems, such as Inflammatory Bowel Disease (IBD) or Irritable Bowel Syndrome (IBS).BACKGROUND OF THE INVENTION[0002]The microflora of the human large intestine (typically divided into caecum, colon and rectum) plays a crucial role in both human nutrition and health. The bacterial composition is influenced and can be modulated by dietary intake. Carbohydrates which have passed through the stomach and small intestine are metabolised by the bacteria and as a major end-pro...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/733A61K31/702A23L1/09A23L1/30A23L29/244A23L33/00A61K31/01A61K31/715
CPCA23L1/0528A23L1/09A61K31/733A61K31/715A61K31/702A61K31/01A23V2002/00A23L1/296A23L1/30A23L1/3081A61K2300/00A23V2250/28A23V2250/5046A23V2200/3202A23V2250/5062A23V2200/304A23V2200/318A23L29/244A23L29/30A23L33/40A23L33/10A23L33/22A23L5/00A23L7/00A23L33/125A61P1/00A61P1/04A61P1/06A61P1/10A61P1/14A61P17/00A61P21/02A61P29/00A61P3/02A61P37/08
Inventor SPEELMANS, GELSKEPETRONELLA GOVERS, MARIA JOHANNA ADRIANAKNOL, JANFRANCISCUS VAN TOL, ERIC ALEXANDER
Owner NV NUTRICIA
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