Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method of producing a nicotine medicament and a medicament made by the method

a nicotine and method technology, applied in the field of nicotine medicaments, can solve the problems that current tobacco replacement therapies have not been effective in satisfying a person's craving for cigarettes, and achieve the effects of reducing aggregation of particles, avoiding irritation, and facilitating aerosolization of particles

Inactive Publication Date: 2012-02-23
SANSA BARBADOS
View PDF0 Cites 30 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The patent describes a new method for producing a nicotine medicament that can be used in tobacco replacement or withdrawal therapy. The medicament is made up of discrete particles that are a combination of nicotine and a carrier. The carrier helps to transport the nicotine to the alveoli and lower airways of the person's lungs. The method involves combining nicotine, a non-spheronized pharmaceutical grade sugar, and a liquid carrier to create a flowable mixture. The mixture is then spray dried to form particles that can be inhaled by the person. The resulting medicament is a more effective and effective way to deliver nicotine to the lungs. The method can also be used to produce a powdered medicament that can be inhaled without causing irritation to the throat or upper airways. The particles have a spherical shape and an uneven surface, which improves their aerodynamic properties and makes them easier to inhale."

Problems solved by technology

Current tobacco replacement therapies have not been effective in satisfying a person's craving for cigarettes.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of producing a nicotine medicament and a medicament made by the method
  • Method of producing a nicotine medicament and a medicament made by the method
  • Method of producing a nicotine medicament and a medicament made by the method

Examples

Experimental program
Comparison scheme
Effect test

examples

[0068]3 g of nicotine and 27 g of lactose were added to 200 g of water. The mixture was stirred until the solution was clear (approximately 10 minutes). The mixture was spray dried in a Buchi Mini Spray Dryer 190, with an air flow rate of 500 ml / minute, an inlet temperature of 165° C. and an outlet temperature of 87° C. The nicotine and lactose solution was fed into the atomizer at a rate of 7 ml / min. The results are set out in Table 1.

[0069]This experimental procedure was repeated under each of the sets of conditions set out in Table 1. Determination of the nicotine content in the nicotine lactose composite product was determined by using UV spectrophotometry at a wavelength of 262 nm. Particle size was determined using laser diffraction methods known in the art.

[0070]A concentration of 3% (w / v) of nicotine in solution, with a 4:6 ratio of nicotine to lactose (w / w) produced the highest concentration in the finished product. An air flow higher than 750 ml / min. resulted in a wet powd...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

A method of producing a nicotine medicament for use in an inhaler comprises combining nicotine, a non-spheronized sugar and a liquid carrier including water to produce a flowable mixture and spray drying the flowable mixture at conditions to produce particles of the nicotine medicament suitable for delivery to the alveoli and lower airways of the person. Also disclosed is a nicotine medicament made by the method. The nicotine composition produced by this method is a composite particle suitable for tobacco replacement or withdrawal therapy.

Description

[0001]This application is a continuation-in-part of application Ser. No. 11 / 673,813 filed Feb. 12, 2007 which is still pending, which is a continuation of application Ser. No. 10 / 320,479 filed Dec. 17, 2007 which is abandoned, which is a division of application Ser. No. 09 / 759,304 filed on Jan. 16, 2001 and which is abandoned, which is a continuation of Ser. No. 09 / 265,367 filed Mar. 10, 1999, which is abandoned, all of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]This invention relates to nicotine medicaments. In particular, the invention relates to a method of producing a nicotine medicament which is suitable for inhalation.BACKGROUND OF THE INVENTION[0003]Smoking has been determined to be a contributory or causative factor in a number of diseases including respiratory diseases such as emphysema, chronic bronchitis, lung infections and lung cancer. Most regular smokers become addicted to, or dependent upon, the pharmacological effects of nicotine in tobacc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): A24F47/00
CPCA61K31/44A61K9/0073A61K9/0075
Inventor PISKORZ, HANNA
Owner SANSA BARBADOS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com