Composition containing metal-acidic amino acid chelate accelerating absorption of metal

Abstract

Provided is a composition for accelerating absorption of metals, comprising a metal-acidic amino acid chelate as an active ingredient. The composition of the present invention has therapeutic effects on prevention and treatment of various diseases arising from a deficiency or shortage of metals, by utilization of a metal-acidic amino acid chelate that exhibits excellent effects of improving delivery and absorption of a drug into target organs, such that pharmaceutical effects of individual metals can be exerted. In particular, a pharmaceutical composition comprising a zinc-aspartate chelate increasing an intraprostatic zinc content as an active ingredient is highly effective for prevention and treatment of prostate and testicular diseases.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a composition for accelerating absorption of metals, comprising a metal-acidic amino acid chelate as an active ingredient. More specifically, the present invention relates to a composition for accelerating absorption of metals, comprising a complex (chelate) of an acidic amino acid and a metal as an active ingredient, wherein the chelate exhibits an excellent activity by having superior improvements in delivery and absorption of metals into target organs so as to exert pharmaceutical effects of individual metals, and a pharmaceutical, sitological or cosmetic composition comprising the same. Among the compositions of the present invention, particularly the pharmaceutical composition comprising a zinc-aspartate chelate capable of increasing an intraprostatic zinc content as an active ingredient is highly effective for prevention and treatment of prostate and testicular diseases.BACKGROUND OF THE INVENTION[0002]The prostate i...

AI Technical Summary

Benefits of technology

[0026]As a result of a variety of extensive and intensive studies and experiments to solve the problems and disadvantages as described above, the inventors of the present invention have confirmed that a metal-acidic amino acid chelate exhibits excellent absorption effects thereof into the target organ and therefore is remarkably effective for prevention and treatment of various diseases arising from a deficiency or shortage of metals or various diseases requiring a supply of metals. The present invention has been completed based on these findings.

[0028]It is another object of the present invention to provide a pharmaceutical composition comprising, as an active ingredient, a metal-acidic amino acid chelate, particularly a zinc-aspartate chelate, in order to achieve normal development of genital organs, functional maintenance of the prostate, production and activity of gonadal hormones (e.g. gonadotropin), production of insulin, synthesis of nucleic acids and proteins, a certain action on the gustatory center and periphery, growth and development of infants, and enhancement of immune functions, or in order to exert therapeutic effects on various diseases and conditions such as underdevelopment of infants, recession of sexual function, anorexia, prostate disorders, thyroid hyperfunction, a decreased resistance to diseases, gustatory dysfunction, glucose metabolic abnormalities, diabetes, alopecia and the like, which may occur due to the deficiency of a certain metal such as zinc.

Problems solved by technology

Due to such anatomical characteristics of the prostate, males often suffer from problems associated with urination as they grow older.

That is, prostate diseases are common diseases with a very low-complete recovery, so about 80 to 90% of the prostate patients suffer from highly severe problems associated with a relapse of the disease.

Further, these symptoms become severe after alcoholic drinking or overwork, which may thereby result in systemic symptoms such as sexual dysfunction, premature ejaculation and physical fatigue.

Further, it is difficult to make a correct diagnosis and further difficult to achieve a treatment of the chronic prostatitis.

In this connection, even though there are introduced various methods for treatment of prostatitis and relaxed diseases, merely minorities of them are known to exhibit limited effects on treatment of prostatitis.

In addition, none of standard therapies and regimens improve health of the prostate.

Onset of prostatic hypertrophy including benign prostatic hypertrophy (BPH) is accompanied by various inconveniences and unbearable symptoms, and may also require a surgical operation in severe cases.

A more serious problem is in that the patient cannot be completely cured due to a difficulty to achieve a complete recovery.

However, when such a drug treatment is not effective, prostatectomy may be conducted using an endoscope.

Unfortunately, these drugs sometimes cause adverse side effects and fail to prevent a recurrence of disease concerned.

However, it was not still revealed that such a drug is practically beneficial to treat prostatitis.

Further, as an allopathic therapy, symptoms of prostatitis are mitigated by massaging the prostate region with hot water, even though there is a limitation in fundamental remedy of the disease.

As discussed hereinbefore, direct injection of antibiotics into the prostate to treat prostate diseases is advantageous to directly deliver a high concentration of a drug without causing systemic side effects, due to direct injection of the drug into a target lesion, but suffers from a disadvantage associated with a short working time of the drug.

In spite of such a fact, available therapeutic drugs are limited because the prostate is located in a deep site of the body and prostate cells have a unique envelope that allows poor passage of drugs.

Further, absorption of the drug into the prostate is not easy, thereby making it difficult to achieve effective treatment.

In particular, treatment of prostatitis may bring about undesirable drug resistance due to chronic administration of the antibiotic, and may also suffer from a problem that the in vivo balance may be collapsed due to a decreased number of normal bacteria.

In other words, oral administration of zinc is not easy due to poor absorption of zinc into the prostate, so there are still no effective methods for treatment of prostate diseases utilizing zinc, except for injection of zinc.

However, infusion of zinc via an injection route suffers from limitations in practical application thereof due to various problems such as the risk of infection, a difficulty in injection, and discomfort and pain to patients.

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