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Intervertebral Disc Repair, Methods and Devices Therefor

a technology of intervertebral discs and repair methods, applied in the field of intervertebral discs, can solve the problems of significant health care, economic and social costs, and unfavorable height or posture changes, and achieve the effects of reducing the risk of injury

Inactive Publication Date: 2008-12-04
VELOCITY FINANCIAL GRP INC ITS SUCCESSORS & ASSIGNS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach allows for the effective repair and supplementation of degenerative intervertebral discs, with the chondrocytes producing a cartilaginous matrix that integrates with surrounding tissues, reducing the risk of immunological rejection and providing a viable alternative to existing treatments.

Problems solved by technology

Intervertebral disc degeneration is a leading cause of pain and disability in the adult population.
The morbidity associated with disc degeneration and its spectrum of associated spinal disorders is responsible for significant health care, economic and social costs.
Furthermore, changes in disc morphology, such as disc compression associated with aging, can lead to unwanted changes in height or posture.
Current treatments for repairing or ameliorating disc degeneration, such as spinal fusion, can be expensive, painful, or lengthy.

Method used

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  • Intervertebral Disc Repair, Methods and Devices Therefor
  • Intervertebral Disc Repair, Methods and Devices Therefor
  • Intervertebral Disc Repair, Methods and Devices Therefor

Examples

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example

[0041]The following example illustrates transplantation and survival of human chondrocytes transplanted into canine intervertebral disc tissue. In this example, a pilot animal study was conducted to determine whether human articular chondrocytes survive injection to produce cartilaginous matrices in experimental defects created in the intervertebral disk of adult canines. Gross morphologic and histological results obtained from this short-term pilot study (12 weeks) demonstrate that implanted chondrocytes can survive to produce cartilaginous matrices which integrate with surrounding host tissues.

[0042]Surgical Procedure: Prior to induction of anesthesia, six adult female dogs were sedated by the attending veterinarian or the veterinary technician / anesthetist using one of the following combinations: Atropine 0.05 mg / kg IM with or without Acepromizine 0.05-0.2 mg / kg IM. An 18 or 20 gauge 1¼ to 2 inch angio-catheter was placed in the cephalic saphenous or auricular vein for venous acce...

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Abstract

The present application discloses compositions, methods and devices for treatment of a degenerative intervertebral disc. A composition can comprise chondrocytes expressing type II collagen. These chondrocytes can be obtained from human cadavers up to about two weeks following death, and can be grown in vitro. The compositions can further comprise one or more biocompatible molecules. Treatment of a degenerative disc can comprise injecting or implanting a composition comprising the chondrocytes into a degenerative disc.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuing application claiming the benefit of priority from U.S. patent application Ser. No. 11 / 063,183 filed Feb. 22, 2005, which claims priority from U.S. Provisional Application Ser. No. 60 / 706,133 filed on Aug. 4, 2005, the disclosures of which are incorporated herein by reference in their entirety.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]Not Applicable.BACKGROUND OF THE INVENTION[0003]Intervertebral disc degeneration is a leading cause of pain and disability in the adult population. Approximately 80% of the population experience at least a single episode of significant back pain in their lifetimes. For many individuals, spinal disorders become a lifelong affliction. The morbidity associated with disc degeneration and its spectrum of associated spinal disorders is responsible for significant health care, economic and social costs. Furthermore, changes in disc morphology, such as disc ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/32A61P19/00A61K35/12A61K45/00C12N5/077
CPCA01K2207/15A01K2217/00A01K2227/10A01K2267/03A61K35/12A61K35/32A61K38/39A61K38/4833C12N5/0655C12N2533/56A61P19/00
Inventor SEYEDIN, MITCHELL S.SPIRO, ROBERTADKISSON, IV, H. DAVIS
Owner VELOCITY FINANCIAL GRP INC ITS SUCCESSORS & ASSIGNS
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