Abuse-resistant oral dosage forms and method of use thereof
a technology of abuse-resistant substances and oral dosage forms, which is applied in the direction of drug compositions, biocide, heterocyclic compound active ingredients, etc., can solve the problems of high potential abuse of oxycodone, high potency of addiction or abuse of such drugs, and euphoric “high” experienced by abusers, and achieve the effect of antagonizing the opioid effect of an opioid agonis
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[0049]In these examples, embodiments of the oral dosage form of the invention were prepared as follows.
Step 1: Applying an Opioid Antagonist Layer to a Biologically Inert Pellet
[0050]
IngredientsExample 1Example 2naltrexone hydrochloride50grams531gramshydroxypropylmethyl cellulose50grams530grams(HPMC) (methocel E6 10%solution) (i.e., 90% water)purified water175grams1050gramssimethicone 30% emulsion1gram10grams(i.e., 70% water)25 / 30 mesh sugar spheres750grams413gramstotal weight:805.3grams1000gramsNote:the water is evaporated during this process and is thus not part of the total weight.
Method
[0051]An opioid-antagonist suspension was prepared by mixing the methocel E6 10% solution (binder agent), the naltrexone hydrochloride (opioid antagonist), the simethicone 30% emulsion (antifoam agent) and the purified water (in the amounts listed above for each example). This opioid-antagonist suspension was then sprayed onto the 25 / 30 mesh sugar spheres using a fluid bed processor, resulting in ...
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