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Multi-layered coatings and methods for controlling elution of active agents

a technology of active agents and coatings, applied in the direction of packaging foodstuffs, prostheses, packaged goods, etc., can solve the problems of peptides and proteins being delivered either more quickly or more slowly, and posing a challeng

Inactive Publication Date: 2008-03-27
SURMODICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is about a method for controlling the release of active agents from a substrate using a multi-layered coating. The coating includes a base layer made of a polymer and an active agent, a solvent, and a layer of parylene. The method involves depositing the coating solution onto the substrate and removing the solvent to reach a desired concentration. The resulting substrate can be used in various applications such as medical devices. The technical effect of this invention is to provide a controlled and sustained release of active agents from a substrate.

Problems solved by technology

Of these compounds, peptides and proteins can pose a challenge because, in general, they are susceptible to denaturation.
In addition, the unique properties of peptides and proteins, such as their relatively large size, can frequently result in them being delivered either more quickly or more slowly than desired.

Method used

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  • Multi-layered coatings and methods for controlling elution of active agents
  • Multi-layered coatings and methods for controlling elution of active agents
  • Multi-layered coatings and methods for controlling elution of active agents

Examples

Experimental program
Comparison scheme
Effect test

example 1

Parylene Coat Over Non-Degradable Hydrophobic Matrix

[0089]Poly-n-butylmethacrylate (PBMA) and polyethylene-co-vinyl acetate (PEVA) were combined in a solvent of chloroform to form a non-degradable polymer solution having 10 mg / ml PBMA and 10 mg / ml PEVA (total solids concentration of 20 mg / ml).

[0090]IgG rabbit anti-goat antibodies were obtained from Sigma-Aldrich, St. Louis, Mo. The IgG rabbit anti-goat antibodies were combined with non-specific IgG rabbit antibodies at a ration of 10:1 non-specific to specific in PBS (phosphate buffered saline) to form an IgG solution.

[0091]MP-35N alloy coils (N=7) were simultaneously coated with both the non-degradable polymer solution and the IgG solution. The non-degradable polymer solution was applied onto the exterior surface of a first ultrasonic nozzle (60 KHz ultrasonic nozzle from Sono-Tek, Milton, N.Y., operating at about 0.5 to 1.5 watts) at a rate of 0.025 mL / minute. Simultaneously, the IgG solution was applied onto the exterior surface ...

example 2

Effects of Vacuum Drying on Elution Rate

[0095]Poly-n-butylmethacrylate (PBMA) and polyethylene-co-vinyl acetate (PEVA) were combined in a solvent of chloroform to form a non-degradable polymer solution having 12.5 mg / ml PBMA and 12.5 mg / ml PEVA (total solids concentration of 25 mg / ml).

[0096]IgG rabbit anti-goat antibodies were obtained from Sigma-Aldrich, St. Louis, Mo. The IgG rabbit anti-goat antibodies were combined with non-specific IgG rabbit antibodies at a ration of 10:1 non-specific to specific in PBS (phosphate buffered saline) to form an IgG solution with a concentration of 20 mg / ml of IgG.

[0097]MP-35N alloy coils (N=4) were segregated into two experimental groups (Group 1 (N=2) and Group 2 (N=4)). The non-degradable polymer solution and the IgG solution were simultaneously deposited onto the coils. Specifically, the non-degradable polymer solution was applied onto the exterior surface of a first ultrasonic nozzle (60 KHz ultrasonic nozzle from Sono-Tek, Milton, N.Y., oper...

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Abstract

Embodiments of the invention include multi-layered coatings for controlling the elution rates of active agents and methods. In an embodiment, the invention includes a method of applying an elution control coating to a substrate. The method can include depositing a coating solution onto the substrate to form a base layer. The method can also include selecting a desired concentration of the solvent based on a desired elution rate. The method can further include removing solvent from the base layer to reach a desired concentration of the solvent and depositing a layer of parylene on the base layer. In an embodiment, the invention can include a medical device including a substrate, a base layer, and a porous layer. The base layer can include a polymeric matrix and an active agent dispersed within the polymeric matrix. The porous layer can include parylene. Other embodiments are also included herein.

Description

[0001]This application claims the benefit of U.S. Provisional Application No. 60 / 826,823, filed Sep. 25, 2006, the content of which is herein incorporated by reference.FIELD OF THE INVENTION[0002]The present invention relates to coatings and methods for controlling the elution of active agents. More specifically, the present invention relates to multi-layered coatings and methods for controlling the elution of active agents.BACKGROUND OF THE INVENTION[0003]Active agent elution control coatings are now commonly used to deliver active agents to tissues of the body. Elution control coatings can enable the delivery of an active agent over a period of time in order to optimize therapeutic effect. In addition, when disposed on a medical device, elution control coatings can enable site-specific active agent delivery because the medical device can be positioned as desired within the body of a patient.[0004]A desirable elution rate for an active agent in one treatment scenario may be differe...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/00A61L27/34
CPCA61L27/34A61L27/54A61L31/10A61L31/16A61L2300/608A61L2420/08C08L65/04
Inventor CHAPPA, RALPH A.
Owner SURMODICS INC
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