Hydrogel-supported porous semiconductor devices

a technology of porous semiconductors and hydrogels, applied in bandages, instruments, diagnostic recording/measuring, etc., can solve the problems of limiting device function, unable to meet challenges in part, and no noninvasive means of detection, so as to improve treatment efficiency, improve treatment efficiency, and improve treatment

Inactive Publication Date: 2007-08-09
UNIVERSITY OF ROCHESTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013] The present invention is an innovative technology that will advance wound care management to an unprecedented level. By accelerating the healing process and preventing significant or harmful infection through early detection, the present invention will assist health care professionals in achieving optimum patient outcomes while lowering treatment costs. The underlying sensor technology has already been demonstrated (see U.S. patent application Ser. No. 10 / 082,634 to Chan et al., which is hereby incorporated by reference in its entirety), and is extensible to a broad range of diagnostic modalities where portable biosensing is desired, such as in the home, work place, or battlefield.

Problems solved by technology

Currently there is no noninvasive means to detect the presence of pathogenic organisms prior to the onset of infection, which is the leading impediment to wound healing followed by lack of blood flow to bilateral extremities.
The challenge for the wound care professional is to be able to recognize the onset of the critical colonization condition that precedes infection and when inhibition of wound healing begins.
This architecture may limit device function, particularly for microfluidic porous structures for which optimum function may depend on the directionality of flow through the device.
This challenge has not been met in part due to the inability to cost-effectively package a reliable and simple-to-use sensor chip technology into a flexible wound care product.

Method used

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Examples

Experimental program
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example 1

on of Porous Semiconductor Material

[0063] Details of exemplary mesoporous silicon λ / 2 microcavity fabrication methods are described in, e.g., Vinegoni et al., in Nalwa, ed., Silicon Based Materials and Devices: Properties and Devices, Vol. 2, Academic Press, pg. 124 (2001), and DeLouise & Miller, Proc. SPIE, 5357:111 (2004), each of which is hereby incorporated by reference in its entirety. Briefly, a multilayer microcavity was fabricated by anodic electrochemical etching of a p+ silicon wafer using an ethanolic 14% HF electrolyte. A constant current density was applied for a fixed time and cycled between different current densities to produce a multilayer device with different porosity layers. A current density of 20 mA / cm2 at an etch rate of ˜18 nm / sec produces a low porosity layer of ˜65%. A current density of 70 mA / cm2 at an etch rate of ˜37 nm / sec produces a higher porosity layer of ˜85%. Each mirror used in this Example contains 9 periods of high and low porosity layers. Poro...

example 2

ydrogel-Supported Porous Semiconductor Material

[0066] Hydrogel-supported porous semiconductor material sensors were prepared by either laminating the released porous semiconductor material directly onto pre-cross-linked gel or by pouring an activated solution of monomer over the microcavity prior to the onset of cross-linking. Synthetic (polyacrylamide, polyvinyl pyrrolidone) and natural (agarose) hydrogels and their mixtures were used.

[0067] Alternatively, the released porous semiconductor material was laminated onto pre-cross-linked commercially available wound care products, for example NU-GEL® Wound Dressing sheet (Johnson and Johnson) (“NU-GEL® sheet”), NU-GEL® Collagen Wound Gel (Johnson and Johnson) (“NU-GEL®Gel”), 3M™ Tegaderm™ Absorbent Clear Acrylic Dressing (3M), and ClearSite® TM Transparent Membrane sheet (ConMed). Commercial bandages offer a unique advantage in that they are typically packaged in a semi-dehydrated state and they are engineered with tack on the gel-mat...

example 3

f Optical Response, Stability, and Sensitivity of the Hydrogel-Supported Porous Semiconductor Material

[0069] A porous semiconductor material (˜5.2 μm thick) was constructed from p+ silicon with 9 periods per mirror of a high porosity (85%) and low porosity (˜65%), tuned to operate in the visible spectrum with a resonance dip at 725 nm, and transferred by contact lamination to a NU-GEL® sheet, shown in FIG. 5.

[0070] The optical response before transfer, immediately after transfer, 3 days after transfer, and 1 year following transfer is shown in FIG. 6. The porous semiconductor material resonance undergoes a large red wavelength shift of ˜150 nm resulting from transfer to the hydrogel. The magnitude of the red shift is consistent with optical simulations in which air in the pores is displaced 100% with water (η=1.33) (see DeLouise & Miller., Proc. SPIE, 5357:111 (2004), which is hereby incorporated by reference in its entirety). FIG. 6 also demonstrates how remarkably stable the sens...

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Abstract

A product including a hydrogel matrix and a porous semiconductor material at least partially embedded within the hydrogel matrix. Also disclosed are methods of making the product and a substantially flexible porous semiconductor material, as well as methods of using the product to deliver a therapeutic agent to a subject and detecting the presence of a pathogen and / or infection at a wound site.

Description

[0001] This application claims the benefit of U.S. Provisional Patent Application Ser. No. 60 / 563,618, filed Apr. 20, 2004, which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION [0002] The present invention relates generally to hydrogel-supported porous semiconductor devices, their methods of manufacture, and their use in wound repair, drug delivery, and pathogen and infection detection at a wound site. BACKGROUND OF THE INVENTION [0003] The current state of wound care product innovation centers around developing new materials that achieve key requirements of exudate adsorption, protection against infection, debridement, odor control, and maintaining hydration. Currently there is no noninvasive means to detect the presence of pathogenic organisms prior to the onset of infection, which is the leading impediment to wound healing followed by lack of blood flow to bilateral extremities. The challenge for the wound care professional is to be able to recognize t...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B32B27/32
CPCA61B5/0059A61B5/445A61F13/00Y10T428/1334G01N33/54373A61B5/412A61K49/0073
Inventor DELOUISE, LISAMILLER, BENJAMIN L.
Owner UNIVERSITY OF ROCHESTER
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