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Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response

a technology of inflammatory response and synergistic composition, which is applied in the field of synergistic composition, can solve the problems of increasing asthma, increasing the sensitivity of consumers to allergens, and complicated issues, so as to improve the rate of glucosamine, reduce the symptoms of osteoarthritis, and normalize the movement of joints

Inactive Publication Date: 2006-06-15
METAPROTEOMICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0033] Preferred embodiments further provides a composition to increase the rate at which glucosamine or chondrotin sulfate function to normalize joint movement or reduce the symptoms of osteoarthritis.

Problems solved by technology

Sensitivity to allergens is a problem for an increasing number of consumers.
This issue has been complicated by a surprising increase in asthma over the past few years.

Method used

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  • Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
  • Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response
  • Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response

Examples

Experimental program
Comparison scheme
Effect test

example 1

AGS GASTRIC MUCOSAL CELLS CONSTITUTIVELY EXPRESS BOTH CYCLOOXYGENASE-1 AND CYCLOOXYGENASE-2

[0126] Summary—This example demonstrates that the AGS human gastric mucosal cell line, possessing constitutive expression of COX-1 and COX-2, has excellent potential to serve as a model for assessing the gastrointestinal toxicity of cyclooxygenase-inhibiting compounds.

[0127] Equipment used in this example included: an OHAS Model #E01140 analytical balance, a Forma Model #F1214 biosafety cabinet (Marietta, Ohio), various pipettes to deliver 0.1 to 100 μL (VWR, Rochester, N.Y.), a cell hand tally counter (VWR Catalog #23609-102, Rochester, N.Y.), a Forma Model #F3210 CO2 incubator (Marietta, Ohio), a hemacytometer (Hausser Model #1492, Horsham, Pa.), a Leica Model #DM IL inverted microscope (Wetzlar, Germany), a PURELAB Plus Water Polishing System (U.S. Filter, Lowell, Mass.), a 4° C. refrigerator (Forma Model #F3775, Marietta, Ohio), a vortex mixer (VWR Catalog #33994-306, Rochester, N.Y.), a...

example 2

INHIBITION OF PGE2 SYNTHESIS IN GASTRIC MUCOSAL CELLS BY NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

[0135] Summary—This example illustrates that inhibition of PGE2 synthesis in AGS gastric cells by NSAIDs correlates with their observed clinical gastric irritation.

[0136] Chemicals—Rofecoxib and celexocib were obtained. Diisofluorophosphate (DIFP), nimensulide, ibuprofen, salicylic acid, aspirin, indomethacin and acetaminophen were purchased from Sigma (St. Louis, Mo.). All other chemicals were obtained from suppliers as described in Example 1.

[0137] Cells—A549 (human pulmonary epithelial) and AGS cells (human gastric mucosa) were obtained from the American Type Culture Collection (Manassas, VA) and sub-cultured according to the instructions of the supplier. The cells were routinely cultured at 37° C. with 5% CO2 in RPMI 1640 containing 10% FBS, with 50 units penicillin / mL, 50 μg streptomycin / mL, 5% sodium pyruvate, and 5% L-glutamine. On the day of the experiments, exponentially growing ...

example 3

INHIBITION OF PGE7 SYNTHESIS IN STIMULATED AND NONSTIMULATED

[0147] MURINE MACROPHAGES BY HOPS (Humulus lupulus) COMPOUNDS AND DERVIATIVES

[0148] Summary—This example illustrates the potency of hops fractions and derivatives to inhibit COX-2 synthesis of PGE2 preferentially over COX-1 synthesis of PGE2 in the murine macrophage model.

[0149] Chemicals and reagents—Bacterial lipopolysaccharide (LPS; B E. coli 055:B5) was from Sigma (St. Louis, Mo.). Hops fractions (1) alpha hop (1% alpha acids; AA), (2) aromahop OE (10% beta acids and 2% isomerized alpha acids , (3) isohop (isomerized alpha acids; IAA), (4) beta acid solution (beta acids BA), (5) hexahop gold (hexahydro isomerized alpha acids; HHIAA), (6) redihop (reduced isomerized-alpha acids; RIAA), (7) tetrahop (tetrahydro-iso-alpha acids THIAA) and (8) spent hops were obtained from Betatech Hops Products (Washington, D.C., U.S.A.). The spent hops were extracted two times with equal volumes of absolute ethanol. The ethanol was rem...

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Abstract

A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This patent application is a continuation-in-part of U.S. application Ser. No. 10 / 400,293, filed Mar. 26, 2003, and a continuation-in-part of U.S. application Ser. No. 10 / 401,283, filed Mar. 26, 2003, both of which claim the benefit under 35 U.S.C. §119(e) to provisional application No. 60 / 450,237, filed on Feb. 25, 2003, and provisional application No. 60 / 420,383, filed on Oct. 21, 2002. The contents of each of these earlier applications are hereby incorporated by reference as if recited herein in their entirety.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] The present invention relates generally to synergistic compositions that treat or inhibit pathological conditions associated with tissue-specific activation of inflammation and to methods of modulating inflammation in cells. More specifically, the invention relates to composition comprising a fraction isolated or derived from hops along with a synergist, such a...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/12A61KA61K31/122A61K31/19A61K31/215
CPCA61K31/12A61K31/122A61K36/185A61K36/53A61K2300/00A61P1/02A61P1/04A61P11/00A61P11/02A61P11/06A61P11/08A61P11/16A61P15/00A61P17/00A61P17/02A61P17/04A61P17/06A61P19/02A61P19/04A61P19/06A61P21/04A61P25/00A61P25/06A61P25/28A61P27/02A61P29/00A61P35/00A61P37/00A61P37/02A61P37/08A61P43/00A61P7/06A61P7/10A61P9/10A61P3/10
Inventor TRIPP, MATTHEW L.BABISH, JOHN G.BLAND, JEFFREY S.DARLAND, GARY K.LERMAN, ROBERTLUKACZER, DANIEL O.LISKA, DEANN J.HOWELL, TERRENCE
Owner METAPROTEOMICS
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