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Imidazole alkaloids from lepidium meyenii and methods of usage

a technology of imidazole and alkaloids, which is applied in the field of new drugs, can solve the problems of poor highland livestock reproduction in the spanish highlands

Inactive Publication Date: 2005-08-04
PURE WORLD BOTANICALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention is about two new compounds, called 1,3-bis(phenylmethyl)-4,5-dimethyl-1H-imidazlium chloride and 1,3-bis(phenylmethyl)-2,4,5-trimethyl-1H-imidazlium chloride, which have been isolated from a root extract of Lepidium meyenii Walp, also known as Maca. These compounds have been found to have anti-proliferative properties, making them useful for treating diseases such as cancer. The patent text describes the use of these compounds for this purpose and provides methods for their use."

Problems solved by technology

Soon after the Spanish conquest in South America, the Spanish found that their livestock were reproducing poorly in the highlands.
Maca may boost desire but does not share Viagra's erection-enhancing properties.
Although it also appeared to boost the production and movement of sperm, Gonzales said more research was needed as the test had been restricted to a very small sample.

Method used

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  • Imidazole alkaloids from lepidium meyenii and methods of usage
  • Imidazole alkaloids from lepidium meyenii and methods of usage
  • Imidazole alkaloids from lepidium meyenii and methods of usage

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Experimental Section

[0026] Plant Material. The roots of L. meyenii (Solanaceae) were collected in Andean Mountains, Peru in 1998. A Voucher specimen representing this collection has been deposited at the Herbrio de Museo de Historia Natural “J. Prado” Un. H. S., Lima, Peru.

[0027] Extraction and Isolation. The air-dried roots (10 kg) of L. meyenii were washed with water, and then extracted with three changes of 100% SDA. After removal of organic solvent, the resultant extracts (2 kg) was dissolved in 10 L of MeOH with heat at 50° C., followed by adding 7 L of 1N hydroxyl chloride (HCl) solution slowly with stirring and allowed to stand for 4 hours. The acidic H2O—MeOH solvent was separated from the precipitate that was treated the same way twice. After removal of organic solvent, the combined aqueous phase was extracted with methylene chloride (CH2Cl2) (3×4 L). The CH2Cl2 layers were combined and evaporated to dryness to afford extract AE (42 g). The remaining aqueous phase was ce...

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Abstract

The present invention relates to novel imidazole alkaloid compounds that have been isolated as a form of chloride salt from a root extract of Lepidium meyenii Walp, with the common name Maca, and identified below as 1,3-bis(phenylmethyl)-4,5-dimethyl-1H-imidazlium chloride and 1,3-bis(phenylmethyl)-2,4,5-trimethyl-1H-imidazlium chloride, compounds (1) and (2), respectively. The present invention further relates to the use of these novel compounds (1) and (2) to treat proliferative diseases, such as but not limited to cancer.

Description

BACKGROUND OF THE INVENTION [0001] 1. Field of the Invention [0002] The present invention relates to novel imidazole alkaloid compounds that have been isolated as a form of chloride salt from a root extract of Lepidium meyenii Walp, with the common name Maca, and identified as 1,3-bis(phenylmethyl)-4,5-dimethyl-1H-imidazlium chloride and 1,3-bis(phenylmethyl)-2,4,5-trimethyl-1H-imidazlium chloride. More specifically, this invention further relates to the use of these novel compounds to treat proliferative diseases, such as but not limited to cancer. [0003] 2. Description of the State of Art [0004]Lepidium meyenii (commonly referred to as Maca) is indigenous to the Andean Mountains at an altitude of higher than 10,000 feet. To the Andean Indians, Maca is a valuable commodity. Because so little else grows in the region, Maca is often traded with communities at lower elevations for other staples like rice, corn, and beans. The dried roots can be stored for up to seven years. Native Per...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D233/10C07D233/56
CPCC07D233/58A61P35/00
Inventor CUI, BAOLIANGZHENG, BO LINHE, KANZHENG, QUN YI
Owner PURE WORLD BOTANICALS
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