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Method for treating obesity

a technology for treating obesity and obesity, applied in the field of obesity, can solve the problems that the available pharmacological therapies for facilitating weight loss fail to provide adequate benefit to many obese patients, and achieve the effect of enhancing the activity of norepinephrine and/or dopamine and minimizing metabolic risk factors

Inactive Publication Date: 2005-06-30
DUKE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Zonisamide, when used alone or in combination with bupropion, demonstrates significant weight loss with fewer side effects, effectively reducing metabolic risks and improving quality of life indicators, as evidenced by substantial weight loss and reduced waist circumference in clinical trials.

Problems solved by technology

Yet, the available pharmacological therapies to facilitate weight loss fail to provide adequate benefit to many obese patients because of side effects, contraindications or lack of positive response (National Heart, Lung and Blood Institute, Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report, NIH Publication No. 98-4083, September 1998).

Method used

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  • Method for treating obesity
  • Method for treating obesity
  • Method for treating obesity

Examples

Experimental program
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Effect test

example 1

Experimental Details

Subjects

[0024] Sixty-eight subjects were screened for participation and 60 subjects were randomized.

[0025] Inclusion criteria were: male or female, aged 21-50 years, with body mass index (BMI) of ≧30 kg / m2.

[0026] Exclusion criteria were: obesity of a known endocrine origin, such as hypothyroidism and Cushing's syndrome; serious / unstable medical or psychiatric illness; current major psychiatric disorder; current drug or alcohol abuse; history of or current kidney disease or renal calculi; significant liver disease; uncontrolled hypertension; current diabetes mellitus (DM), type 1 or 2 DM receiving pharmacotherapy; untreated or uncontrolled thyroid disease; weight loss or gain greater than four kilograms in past three months; history of obesity surgery; current or recent use of any weight loss medications, herbs, or supplements; current or recent use of drugs, herbs, or dietary supplements known to significantly affect body weight; concomitant medications that...

example 2

[0055] A 35 y.o. obese female (weight 271 lb, BMI 40 kg / m2), who failed to benefit from numerous weight loss interventions, was started on bupropion 150 mg / day and the dose was increased after 5 days to 150 mg twice a day. After one month of treatment, she lost 5 lbs, but regained 3.4 lbs during the second month—thus managing a net weight loss of 1.6 lbs after 2 months on bupropion. At this point, zonisamide was added to the regimen at 100 mg / day and the dose was increased after 2 weeks to 200 mg / day. After one month on the combination therapy, the patient had lost 11 lbs and reported no side effects. No further information is available as the patient has relocated.

example 3

[0056] A 47 y.o. obese female (weight 246 lb, BMI 41.4 kg / m2), who had not benefited from various treatments, was started on zonisamide 100 mg / day and the dose was increased gradually to 400 mg a day over the next 4 weeks. After one month of treatment, she lost 4.6 lbs, but there was no further weight loss during the second month. At this point, zonisamide dose was increased to 600 mg a day; the patient achieved an additional weight loss of 0.6 lb in the next month. Thus, after 3 months of zonisamide therapy, the total weight loss with zonisamide therapy was 5.2 lb. Zonisamide was continued at the same dose and bupropion SR was started at 100 mg a day. After 10 days, the dose of bupropion was increased to 200 mg a day. One month later, the patient had lost 8.2 lbs and reported no side effects. She reported that she felt “full” after eating small portions of food, and had more energy. She had lost over 35 lbs over ten months on the combination therapy with no side effects.

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Abstract

The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and / or dopamine via uptake inhibition or other mechanism.

Description

[0001] This application claims priority from Prov. Appln. No. 60 / 380,874, filed May 17, 2002, the content of which is incorporated herein by reference.TECHNICAL FIELD [0002] The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and / or dopamine via uptake inhibition or other mechanism. BACKGROUND [0003] The prevalence of obesity has risen significantly in the past decade in the United States and many other developed countries, (Fiegal et al, Int. J. Obesity 22:39-47 (1998), Mokdad et al, JAMA 282:1519-1522 (1999)). Because obesity is associated with a significantly elevated risk for type 2 diabetes, coronary heart disease, hypertension, and numerous other major illnesses, and overall mortali...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/137A61K31/255A61K31/35A61K31/357A61K31/42A61K31/423A61K31/5375A61K31/7024A61K31/7028A61K45/06A61P3/04A61P3/06A61P3/10A61P9/12
CPCA61K31/137A61K31/255A61K31/35A61K31/357A61K31/42A61K45/06A61K31/423A61K31/7024A61K2300/00A61P3/04A61P31/04A61P3/06A61P43/00A61P9/12A61P3/10
Inventor GADDE, KISHORE M.KRISHNAN, K. RANGA R.
Owner DUKE UNIV
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