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Novel human calcium dependent proteases, polynucleotides encoding the same, and uses thereof

a polynucleotide and protein technology, applied in the field of discovery, identification, and characterization of novel human polynucleotides encoding proteins, can solve problems such as unsatisfactory use, and achieve the effects of increasing or decreasing nhp activity, reducing white blood cell count, and increasing or decreasing white blood cell coun

Inactive Publication Date: 2004-10-07
DONOHO GREGORY +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention is about the discovery and characterization of novel human proteins (NHPs) that are related to animal calcium-activated proteases, or calpains. These NHPs are encoded by nucleotide sequences that are similar to animal calpains. The invention includes the identification of agonists and antagonists of NHPs, as well as knockout mice that do not express functional NHPs. The unique NHP sequences described in the invention can be used for drug discovery and development, as well as for the treatment of conditions such as low white blood cell count. The invention also includes diagnostic assays and methods for identifying compounds that modulate NHP activity. Overall, the invention provides new information and tools for research and development in the field of human biology."

Problems solved by technology

Although treatments for neutropenia currently exist in the art, they are not ideal for use in all circumstances, and are actually contraindicated in certain patients.

Method used

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Embodiment Construction

[0019] The NHPs, described for the first time herein, are novel proteins that are expressed in, inter alia, human cell lines, and human prostate and testis cells. The described sequences were compiled from gene trapped cDNAs and clones isolated from a human testis cDNA library (Edge Biosystems, Gaithersburg, Md.).

[0020] The present invention encompasses the nucleotides presented in the Sequence Listing, host cells expressing such nucleotides, the sexpression products of such nucleotides, and: (a) nucleotides that encode mammalian homologs of the described polynucleotides, including the specifically described NHPs, and the NHP products; (b) nucleotides that encode one or more portions of the NHPs that correspond to functional domains, and the polypeptide products specified by such nucleotide sequences, including, but not limited to, the novel regions of any active domain(s); (c) isolated nucleotides that encode mutant versions, engineered or naturally occurring, of the described NHPs...

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PUM

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Abstract

Novel human polunucleotide and polypeptide sequences are disclosed that can be used in therapeuutic, diagnostic, and pharmacogenomic applications.

Description

[0001] The present application is a continuation-in-part of co-pending U.S. application Ser. No. 09 / 653,839, filed on Sep. 1, 2000, which claims the benefit of U.S. Provisional Application Serial No. 60 / 152,057, filed Sep. 2, 1999, both of which are herein incorporated by reference in their entirety.1.0 INTRODUCTION[0002] The present invention relates to the discovery, identification, and characterization of novel human polynucleotides encoding proteins that share sequence similarity with human calcium dependent proteases, specifically calpains. The invention encompasses the described polynucleotides, host cell expression systems, the encoded proteins, fusion proteins, polypeptides and peptides, antibodies to the encoded proteins and peptides, and genetically engineered animals that either lack or overexpress the disclosed polynucleotides, antagonists and agonists of the proteins, and other compounds that modulate the expression or activity of the proteins encoded by the disclosed p...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N9/64
CPCC12N9/6472
Inventor DONOHO, GREGORYTURNER, C. ALEXANDER JR.NEHLS, MICHAEL C.FRIEDRICH, GLENNZAMBROWICZ, BRIANSANDS, ARTHUR T.
Owner DONOHO GREGORY
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