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Injection liquid of sodium tanshinon IIA silite

A technology of injection and sodium sulfonate, which is applied in the field of medicine, can solve problems affecting drug safety, product quality decline, easy oxidation and decomposition, etc., and achieve the effects of improving drug safety, improving quality, and simplifying the production process

Inactive Publication Date: 2007-07-11
广东宏远集团药业有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tanshinone IIA Sodium Sulfonate Small-volume Injection is a product that has been approved for marketing. The national drug standard is: WS-10001-(HD-1014)-2002. However, if the product is stored for a long time and exposed to light or high temperature sterilization, the color will become darker and it will be easily oxidized. Decomposition will reduce the quality of the product and affect the safety of medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example I

[0061] Example I: Tanshinone IIA sulfonate sodium glucose injection prescription:

[0062] 1 bottle

[0063] Sodium Tanshinone IIA Sulfonate 20mg

[0064] Sodium Calcium EDTA 20mg

[0065] Glucose 5g

[0066] Hydrochloric acid amount

[0067] Add water for injection to 100ml

[0068] Preparation Process:

[0069] Weigh tanshinone IIA sodium sulfonate, calcium sodium edetate and glucose, add water for injection and stir to dissolve, adjust the pH value to 3.5-5.5 with hydrochloric acid, add water to a sufficient amount, stir evenly, measure the pH value and content after passing the test, Filling, stoppering, capping, sterilization, ready to serve.

example II

[0070] Example II: Tanshinone IIA sulfonate sodium glucose injection prescription:

[0071] 1 bottle

[0072] Sodium Tanshinone IIA Sulfonate 20mg

[0073] Disodium edetate 20mg

[0074] Glucose 5g

[0075] Hydrochloric acid amount

[0076] Add water for injection to 100ml

[0077] Preparation Process:

[0078] Weigh tanshinone IIA sodium sulfonate, calcium sodium edetate and glucose, add water for injection and stir to dissolve, adjust the pH value to 3.5-5.5 with hydrochloric acid, add water to a sufficient amount, stir evenly, measure the pH value and content after passing the test, Filling, stoppering, capping, sterilization, ready to serve.

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PUM

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Abstract

The invention relates to a sodium tanshinone IIA silate injection which comprises the constituents of (by weight percent) tanshinone II A sodium sulfonate 0.1-99. 9%, anti-oxidant 0.1-99. 9%. The medicament can be administered through intramuscular injection or venous instillation, and is mainly used for treating coronary disease, angina pectoris and pain of the chest.

Description

(1) Technical field [0001] The invention relates to a sodium tanshinone IIA sulfonate injection, which belongs to the field of medicine. (2) Background technology [0002] Sodium tanshinone IIA sulfonate encounters high heat and light, the color will deepen, and it is easy to decompose. Tanshinone IIA Sodium Sulfonate Small-volume Injection is a product that has been approved for marketing. The national drug standard is: WS-10001-(HD-1014)-2002. However, if the product is stored for a long time and exposed to light or high temperature sterilization, the color will become darker and it will be easily oxidized. Decomposition will reduce the quality of the product and affect the safety of medication. [0003] (3) Invention Basis [0004] Aiming at the easy oxidative decomposition of tanshinone IIA sulfonate, a safe and effective antioxidant was sought, and the prescription was screened according to the relevant norms of new drug preclinical research. Sodium sulfite, sodium b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61K9/08A61P9/10
Inventor 杨杰蔡惠明罗四通姚海燕陈波
Owner 广东宏远集团药业有限公司
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