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Spatholobus stem drop-pill and its preparation method

A technology of Caulis Spatholobus and dripping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problems of inconvenient taking of granules, high sugar content in syrups, and inconvenient transportation and carrying, and achieves Conducive to human body absorption, high dissolution rate, and the effect of improving bioavailability

Inactive Publication Date: 2007-07-04
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Syrups contain high sugar content, so patients with diabetes should not take them, and they are inconvenient to carry; granules are inconvenient to take and easy to absorb moisture

Method used

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  • Spatholobus stem drop-pill and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Take 2000g of Millet Spatholobus, add water to decoct 2 times, the amount of water added is 8 times the amount for the first time, and 6 times the amount for the second time, the decoction time is 4 hours for the first time, 2 hours for the second time, filter Combine 2 filtrates, be concentrated to the extract that relative density is 1.20 (20 ℃), add ethanol and make alcohol content be 70%, stir evenly, leave standstill for 24 hours, get supernatant and reclaim ethanol, concentrate into extract, The extract is vacuum dried to obtain the extract. Get the extract, pulverize it, and pass through a 100-mesh sieve, and the ratio by weight is Caulis Spatholobus Extract: Polyethylene Glycol 6000 =1:3 ratio, add to the melted matrix (87°C), stir evenly, drop into the simethicone coolant (3°C), separate the dropping pills, absorb the coolant, and dry to obtain.

Embodiment 2

[0018] Embodiment 2: Get 1000g of Spatholobus Spatholobus, add 70% ethanol, the amount added is 8 times the amount for the first time, 6 times the amount for the second time, heat and reflux twice, 4 hours for the first time, 2 hours for the second time, filter ; Merge the 2 filtrates, concentrate to the extract, and vacuum-dry the extract to obtain the extract. Take the extract, crush it, and pass through a 100-mesh sieve. The ratio of Caulis Spatholobus extract by weight: mixed matrix=1:2 (polyethylene glycol 6000 : poloxamer according to the formula of 1:0.2), add to the molten mixed matrix (85 ℃), stir evenly, drop into simethicone or other dropping pill coolant (3 ℃), separate the dropping pill , suction off the coolant, dry, that is.

Embodiment 3

[0019] Example 3: In this example, through the formulation of the extract of Spatholobus Spatholobus and different matrixes, the indicators such as roundness, difference in pellet weight, hardness, and dissolution time are investigated to determine the weight ratio of the extract to a single or mixed matrix.

[0020] The test of Spatholobus extract and different matrix formulations (extracts are 1 part)

[0021]

[0022] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperature of the medicinal material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / minute.

[0023] 2. The above results show that all the indicators of No. 4~11 experiments are good, that is, when the ratio of the extract to the matrix is ​​1:1~1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test No. 4, 6, 8, and 10, that is, the ratio of extract to mat...

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PUM

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Abstract

The invention relates to a medicinal dripping pill of spatholobus stem and its preparation, wherein the medicament possesses functions of enriching blood, promoting blood circulation, relaxing tendon and vein, and can be used for treating hyphemia, asthenia, abnormal menstruation, dysmenorrhea, sallow complexion, anesthesia, paralysis and rheumatalgia. The medicament is prepared from Chinese medicinal herb of spatholobus stem through extracting and mixing extractive with dripping pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying. The medicament also has the advantages of quicker disintegration and dissolution, higher dissolution, quick-speed medicine release, quick-speed effect, simple process for manufacturing, and low cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, in particular to a Caulis Spatholobus dripping pill and a preparation process thereof. Background technique [0002] Spatholobus spatholobus, aliased as Spatholobus suberectus Dunn, is the dried cane of Spatholobus suberectus Dunn. It is warm in nature, bitter in taste, sweet, and returns to the liver and kidney channels. It has the effects of nourishing blood, promoting blood circulation, and dredging collaterals. The modern monograph "Modern Practical Chinese Medicine" describes its treatment: "a strong blood-enriching medicine is suitable for anemic nerve paralysis." In clinical application, Spatholobus Spatholobus is used to treat women's anemia, blood deficiency and chlorosis, etc. Postpartum women often experience symptoms such as pain, numbness, and even pain in joints, waist, limbs, and heels. In traditional Chinese medicine, it is collectively referred to...

Claims

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Application Information

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IPC IPC(8): A61K36/486A61K9/20A61P15/00
Inventor 陈茜滕慧丽
Owner 陈茜
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