Thiazolidinedione oral sugar-lowering drug dropping pill preparation and its preparing method

A technology of thiazolidinedione and hypoglycemic drugs, which is applied in the field of thiazolidinedione oral hypoglycemic drug drop pill preparation and preparation, can solve the problems of drug dissolution and absorption limitation, and achieve improved bioavailability, no dust, The effect of fast dissolution rate

Inactive Publication Date: 2007-06-13
福建东瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Present thiazolidinediones oral hypoglycemic agents are tablets or capsules, because thiazolidinediones such as pioglitazone and rosiglitazone are insoluble drugs, the dissolution and absorption of tablets and capsules are limited Certain restrictions, therefore, the new preparation of developing a kind of thiazolidinediones oral hypoglycemic agent, is people's expectation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription: based on 1000 capsules

[0022] Pioglitazone 15g

[0023] Macrogol 4000 10g

[0024] Macrogol 6000 20g

[0025] Tween 80 0.05g

[0026] tert-butyl-4-hydroxyanisole 5mg

[0027] Sodium carboxymethyl starch 1.5g

[0028] Preparation method: Heat and dissolve the polyethylene glycol in the prescription. After the matrix is ​​melted, add the micronized drug and other excipients, stir evenly, keep warm at 80°C, put it in a dropping pill machine to make pills, drop into 20°C Remove the liquid paraffin from the liquid paraffin, select pellets, dry and pack, to obtain.

Embodiment 2

[0030] Prescription: based on 1000 capsules

[0031] Rosiglitazone 4g

[0032] Macrogol 4000 10g

[0033] Macrogol 6000 30g

[0034] Tween 80 0.1g

[0035] Sodium bisulfite 10mg

[0036] Preparation method: Same as Example 1.

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PUM

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Abstract

The present invention discloses a dripping pills preparation of thiazolidone oral hypoglycemic agent and its preparation method. Said dripping pills preparation is made up by using thiazolidone oral hypoglycemic agent, polyethylene glycol 6000, polyethylene 4000, poloxamer, stearic acid, tert-butyl-4-hydroxyphenyl methyl ether, sodium hydrogen sulfite, Tween-80 and carboxymethyl amylosodium.

Description

technical field [0001] The invention relates to a preparation of thiazolidinedione oral hypoglycemic agents and a preparation method thereof. Background technique [0002] Diabetes is a serious endocrine and metabolic abnormal disease that endangers human health. Poor long-term control will affect many organs of the patient's body, causing lesions in the eyes, heart, kidneys, brain, nerves, blood vessels, lower limbs, feet, etc., and even lead to crippled. It can also directly threaten the life of patients due to acute complications of diabetes such as ketoacidosis and hyperosmolar coma. [0003] Diabetes is one of the diseases with the highest incidence rate in the world, second only to tumors and cardiovascular diseases, ranking third. With the progress of society, the improvement of people's living standards, the extension of life expectancy and the improvement of diabetes detection methods, the prevalence of diabetes is increasing year by year in countries all over the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/426A61K9/20A61P3/10
Inventor 王惠明吴志明
Owner 福建东瑞制药有限公司
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