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Medicine composition containing matrine and astragaloside and its use

A technology of matrine alkaloids and astragalus saponins is applied in the directions of drug combinations, medical preparations containing active ingredients, drug delivery, etc., which can solve problems such as toxic and side effects, and achieve the effects of reducing toxic and side effects, inhibiting growth, and improving drug efficacy.

Inactive Publication Date: 2007-06-06
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The alkaloid components of Sophora flavescens have significant tumor growth inhibitory effects in vivo and in vitro, but have certain toxic and side effects at high doses

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take the coarse powder of Astragalus membranaceus, heat and reflux with an appropriate amount of 50% ethanol to extract the medicinal materials, cool the extract overnight and filter, concentrate the filtrate on D101 macroporous adsorption resin, rinse with water first, then rinse with 30% to 70% ethanol, and absorb Concentrated and freeze-dried. The extract was detected by HPLC-ELSD method, the analysis condition was Agilent Extend-C18, and the mobile phase was H2O-CH 3 CN, the aqueous phase decreased linearly from 70% to 10% within 30min; ELSD parameters: drift tube temperature 105°C, carrier gas flow rate 2.7L / min; Saponin I is the detection component, and its content is determined by external standard method. Wherein the contents of astragaloside I, II and IV are 33%, 17% and 15% respectively, the content of isoastragloside II is 1%, and the content of acetylastragaloside I is 5%.

[0014] Sophora flavescens is crushed, extracted by percolation with 0.1-2% hydroch...

Embodiment 2

[0015] Example 2 Antitumor effect experiment of composition 1 (total alkaloids of matrine: total saponins of astragalus = 1:2)

[0016] The mice pre-inoculated with H22 ascites tumor were sacrificed, and 1ml of ascites tumor was extracted from the abdominal cavity, and diluted with normal saline to 1×10 6 cells / ml, injected into the underarm of ICR female mice at 0.2ml / only, and after 24 hours, they were randomly divided into groups and started to administer. The compositions were administered in high, medium and low doses respectively. After 8 days of continuous administration, the drug was stopped, the mice were weighed, and the tumor pieces were dissected and weighed separately for statistical analysis. See Table 1 for the results.

[0017] group

[0018] Compared with the control group, * P<0.01

Embodiment 3

[0019] Example 3 Synergistic experiment of composition 2 (total alkaloids of matrine: total saponins of astragalus=1:3) and chemotherapeutic drugs

[0020] The mice pre-inoculated with H22 ascites tumor were sacrificed, and 1ml of ascites tumor was extracted from the abdominal cavity, and diluted with normal saline to 1×10 6 cells / ml, injected into the underarm of ICR female mice at 0.2ml / only, and after 24 hours, they were randomly divided into groups and started to administer. The dosage of the chemotherapeutic drug cyclophosphamide is 20 mg / Kg, intramuscular injection, and administered every other day; the dosage of cisplatin is 1 mg / Kg, intraperitoneal injection, and daily administration. The composition was intragastrically administered at a dose of 360 mg / Kg, once a day, and the results are shown in Table 2.

[0021] group

[0022] Compared with the control group, * P** P<0.001

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PUM

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Abstract

The present invention is one kind of medicine composition containing flavescent sophora total alkaloid and astragalus total saponin in the weight ratio of 1 to 0.1-1 to 10. The medicine composition with well combined flavescent sophora total alkaloid and astragalus total saponin has the functions of supporting healthy energy to eliminate evils, reducing toxicity and synergizing, and may be used in inhibiting tumor, raising the medicinal effect of chemotherapeutic medicine and reducing the toxic side effect of chemotherapeutic medicine.

Description

technical field [0001] The invention relates to an anti-tumor pharmaceutical composition, which contains matrine alkaloids and astragaloside in a certain proportion, is mainly used for treating malignant tumors, and has synergistic and attenuating effects on chemotherapeutic drugs. technical background [0002] Years of clinical practice have shown that the combination of traditional Chinese and Western medicine has a positive effect on the prevention and treatment of malignant tumors. Traditional Chinese medicine can relieve symptoms of patients, improve immune function and body condition, improve the curative effect of surgery, radiotherapy or chemotherapy, reduce the resulting toxic and side effects, and improve the quality of life of patients, etc. The effect is remarkable. However, most of the anti-tumor traditional Chinese medicines in the past were composed of large compound prescriptions, and it was difficult to meet the requirements of "safety, effectiveness, and st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61K36/481A61K9/00A61P35/00
Inventor 程翼宇贺庆刘雳瞿海滨水文波
Owner ZHEJIANG UNIV
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