A plane NMR micro-coils micro detector

Abstract

A plane nuclear magnetic resonance micro coil micro detector is disclosed that consists of plane nuclear magnetic resonance micro coil [1] and micro flow channel structure [2]. It adopts the integral design; the plane nuclear magnetic resonance micro coil [1] is processed on the surface of the polyimides substrate [3], the micro flow channel structure [2] is rectangle structure and processed on the other surface of the polyimides substrate [3], it is embedded in the inner of the polyimides substrate [3] which is under the plane nuclear magnetic resonance micro coil [1] by the polyimides slice [4]. When it is working, the plane nuclear magnetic resonance micro coil works as the radio-frequency exciter and the signal receiver at the same time, and actuates the sample to be measured to generate the NMR signal and obtain the NMR wave spectrum. The invention can fulfill the detecting requirements of lossless and real-time, the molecular structure and information of images-structure of detecting sample can be supplied. It can be used in fields of analysis detection of tiny sample, real-time dynamic monitoring of chemical reaction, and biological texture and growth status of cell.

Description

technical field [0001] The invention relates to a planar nuclear magnetic resonance microcoil microdetector. Background technique [0002] Nuclear Magnetic Resonance (NMR) refers to the physical process in which the nuclear magnetic moment is not zero, and under the action of an external magnetic field, the nuclear spin level undergoes Zeeman splitting and resonantly absorbs radio frequency radiation of a specific frequency. Since the size of the Zeeman split is closely related to the chemical structure of the molecule, NMR can provide information about the chemical structure and molecular dynamics and become a powerful tool for molecular structure analysis, which is not available in other analytical methods . The method and technology of nuclear magnetic resonance, as a means of analyzing substances, has been rapidly developed and widely used because it can penetrate deep into the substance without destroying the sample, and has the advantages of rapidity, accuracy, and hi...

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Problems solved by technology

[0010] The purpose of the present invention is to overcome the high brittleness of the substrate in the prior art, which is easy to be destroyed, and cannot be used on rougher surfaces, and the planar microcoil and microchannel structure are respectively processed on different substrates, so that the flow through the microchannel The distance between the sample and the coil of the structure is far away, which reduces the shortcomings of the detection sensitivity. A planar micro-coil NMR micro-detector with a new structure is proposed.

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