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Enteric-coated formulation of creat and preparation process thereof

An enteric-coated preparation, andrographis paniculata technology, applied in the directions of pill delivery, block delivery, medical raw materials derived from angiosperm subphylum, etc., can solve the problems of single chemical composition of western medicine, no problems, complex components, etc., to reduce adverse effects. Probability of reaction, reduced dose, effect of ease of use

Inactive Publication Date: 2007-05-30
徐小彬 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0024] We also learned that the chemical composition of western medicine is single, and the excipients used are generally in accordance with the standards of some developed countries in the world. There will be problems, but for our country, there are many traditional Chinese medicine preparations produced. Due to the complexity of the ingredients, how to choose suitable enteric-coated materials to ensure stable product quality is worth further research.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Preparation of Churographis paniculata enteric-coated capsules: take 1000 kg of Andrographis paniculata, heat and extract twice with 85% ethanol for 2 hours each time, combine the extracts, filter, recover ethanol from the filtrate, concentrate to an appropriate amount, dry, add appropriate amount of auxiliary materials, and prepare Form into granules, put into enteric-coated empty capsules containing HPMCP, and get ready.

Embodiment 2

[0041] Preparation of Andrographis paniculata enteric-coated granules: Take 1000 kg of Andrographis paniculata, heat and extract twice with 85% ethanol for 2 hours each time, combine the extracts, filter, recover ethanol from the filtrate, concentrate to an appropriate amount, dry, add appropriate amount of auxiliary materials, and prepare Granules, containing CAP enteric coating, ready to use.

Embodiment 3

[0043] Preparation of Andrographis paniculata enteric-coated tablets: Take 1000 kg of Andrographis paniculata, heat and extract it twice with 85% ethanol, each time for 2 hours, combine the extracts, filter, recover the ethanol from the filtrate, concentrate to an appropriate amount, dry, add appropriate amount of auxiliary materials, It is made into granules, compressed into tablets, and contains polyacrylic resin enteric coating, that is, the product is obtained.

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PUM

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Abstract

The invention discloses a making method to improve biological utility of creat, which consists of andrographolide and dehydrated andrographolide, wherein the pH value of normal human gastric liquid is 1-3 and gastric secretion liquid is 6-8, which is easy to hydrolyze creat under acid condition and reduces hydrolytic rate under alkaline condition.

Description

technical field [0001] The invention relates to a technical design scheme for improving the bioavailability of the drug andrographis paniculata, and a preparation method of a specific preparation. Background technique [0002] Enteric-coated preparation technology is a mature modern pharmaceutical preparation technology, which belongs to the drug positioning release technology, and is mainly developed for gastric irritating and gastric destructive drugs. At present, there are many types of enteric-coated preparations for chemical drugs, and enteric-coated preparations have also been developed for many commonly used drugs such as aspirin. The research and development of enteric-coated preparations is deepening, and the small intestine absorption has been subdivided to develop enteric-coated preparations. At present, there are no market varieties of Chinese patent medicines developed by enteric-coated preparation technology in China. The state encourages Chinese patent medicin...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61K31/365A61K9/16A61K9/20A61K9/48A61P11/04
Inventor 徐小彬郑作文
Owner 徐小彬
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