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Method for preparing bionic laminar articular cartilage/bone compound implant

A technology of articular cartilage and bionic layer, which is applied in the field of biomedical materials or biocomposite materials, can solve the problems of weak combination of artificial cartilage and base bone, difficulty and risk of surgery, poor fixation effect, etc., to meet the requirements of biomechanical properties and Physiological function, improve binding and immobilization effect, good structure and performance stability effect

Inactive Publication Date: 2007-05-16
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It solves the problems of loose connection, poor fixation effect, weak combination of artificial cartilage and base bone, difficult operation and high risk in clinical artificial cartilage replacement, and improves the replacement effect and physiological function of artificial cartilage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] a. Take the bones at the pig joints, wash them and process them into a cylindrical shape with a diameter of 10.0mm and a thickness of 5.0mm. Rinse repeatedly with a high-pressure water gun for 90 minutes; dry in the air for 2 days; polish the surface of the bone implant with sandpaper, and treat it in an ultrasonic cleaner at room temperature for 45 minutes until the bone cells, bone marrow, collagen and other organic matter in the bone block After washing thoroughly with bone debris, etc., freeze them for storage. Soak in ice water 1 hour before use.

[0020] b. Prepare analytically pure polyvinyl alcohol (PVA) in a constant temperature water bath at 90° C. to prepare a homogeneous solution (solution I) with a concentration of 15% by weight.

[0021] c. Preparation of lubricating layer: add polyvinylpyrrolidone (PVP) to the PVA aqueous solution, the addition amount is 10% of the weight of PVA, after the mixed solution is fully stirred at 90°C, let it stand for 24 hour...

Embodiment 2

[0026] a. Take the bones of pig joints, wash them and process them into square columns with a cross-sectional area of ​​8×8mm 2 , thickness 10.0mm. Rinse repeatedly with a high-pressure water gun for 30 minutes; dry in the air for 1 day; polish the surface of the bone implant with sandpaper, and treat it in an ultrasonic cleaner at room temperature for 30 minutes until the bone cells, bone marrow, collagen and other organic matter in the bone block After thoroughly washing away bone debris and the like, they were frozen and stored (called bone samples). Soak in ice water 1 hour before use.

[0027] b. Prepare analytically pure polyvinyl alcohol (PVA) in a constant temperature water bath at 95° C. to prepare a homogeneous aqueous solution (solution I) with a concentration of 30% by weight.

[0028] c. After dissolving chitosan in 0.5% dilute acetic acid solution for 24 hours, add it to the PVA solution. The amount of chitosan added is 8% of the weight of PVA; after fully stir...

Embodiment 3

[0033] a. Take the bones at the joints of pigs, clean them into a spherical shape, the radius of the spherical surface is 10mm, and the thickness is 15.0mm. Rinse repeatedly with a high-pressure water gun for 150 minutes; dry in the air for 3 days; polish the surface of the bone implant with sandpaper, and treat it in an ultrasonic cleaner at room temperature for 150 minutes until the bone cells, bone marrow, collagen and other organic matter in the bone block After washing thoroughly with bone debris, etc., freeze them for storage.

[0034] b. Dissolve analytically pure polyvinyl alcohol in double-distilled water in a 125MPa pressure cooker to prepare a homogeneous solution (solution I) with a concentration of 20% by weight.

[0035] c. Dissolving hyaluronic acid (HA) in physiological saline to prepare a homogeneous solution-adding to PVA aqueous solution, the concentration of HA in the PVA solution is 0.15% by weight. The above mixed solution was stirred at 95° C. and then ...

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Abstract

The invention relates to a method for preparing bionic laminated cartilage / bone element, wherein it comprises preparing porous same heterogenous bone or different bone elements; preparing artificial cartilage and laminated cartilage / bone composite. The invention processes the bone into needed size and shape, to be washed and immunity treatment, to be put at the bottom of mould; then at positive and passive pressures, pouring the polyvinyl alcohol / biological active component preformed element and polyvinyl alcohol / lubricant molecule preformed element into mould; flattening the surface and compressing; freezing and fusing, shaping. The inventive product has surface layer as abrasion-resistant lubricant layer, middle layer as force layer, and bottom layer as biological active cartilage / bone combine layer, to meet biological physica property and physiological function.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials or biocomposite materials, and in particular provides a method for preparing a bionic layered articular cartilage / bone composite implant. Background technique [0002] The repair and replacement of cartilage tissue is a common operation in clinical surgery. At present, the clinical treatment of articular cartilage mainly adopts autologous or allogeneic cartilage transplantation and artificial cartilage replacement. At present, the artificial cartilage materials that have been studied more mainly include metal-ultra-high molecular weight polyethylene anti-friction joint prosthesis, silicone rubber, polyurethane joint cushion material, polyvinyl alcohol hydrogel, etc. Although these cartilage prostheses can replace cartilage to a certain extent, they still have disadvantages such as easy wear and loosening, poor interface lubrication, and lack of biological activity. The physiological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/42A61F2/30
Inventor 郑裕东姚学峰黄小山徐红王迎军
Owner UNIV OF SCI & TECH BEIJING
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