Dual high immunity immunoglobulin for anti reproduction of pig and breathing syndrome, second type cirque virus of pig

A technology of respiratory syndrome and immunoglobulin, applied in the field of double-linked hyperimmune immunoglobulin, can solve the problems of increased mortality in pig herds, mixed infection and infection of pigs' immunity, obstacles, etc., and achieves short course of treatment, good safety, Ease of use

Inactive Publication Date: 2007-05-09
张中洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, these two diseases often have mixed infections and cause immune disorders in the infected pigs, thereby causing secondary infections of other diseases (such as secondary infections of suis streptococcosis), causing a sharp increase in the mortality rate of pigs. Especially for farms and households that ra

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1. Selection of immunized animals: The immunized animals of the present invention use strictly quarantined pigs and horses (mutes, donkeys) as immunized animals.

[0043] 2, the immunogen of the present invention is prepared by adding complete Freudian's adjuvant after getting cell culture, and cultivating porcine reproductive and respiratory syndrome virus with Marc-145 cells, and the virus calibration value reaches 10 6～8 . Porcine circovirus type 2 was cultivated with PK-15 cells, and the virus calibration value reached 10 5～6 , the two immunogens were mixed in a ratio of 1:2, and Freund's adjuvant was added according to the volume ratio of 1:1 as the immunogen to immunize animals; at the same time, the glycoside injection developed by Jilin Whale Elephant Animal Pharmaceutical Co., Ltd. was used as Immunopotentiator, 5ml / bottle, to increase antibody titer.

[0044] 3. The way of immunization is intradermal, subcutaneous or acupoint or intramuscular multi-point inj...

Embodiment 2

[0053] The immunogen of the present invention is prepared by taking cell culture and adding complete Freud's adjuvant after concentration, and cultivating porcine reproductive and respiratory syndrome virus with Marc-145 cells, and the virus calibration value reaches 10 6～8. Porcine circovirus type 2 was cultivated with PK-15 cells, and the virus calibration value reached 10 5～6 The two immunogens were mixed in a ratio of 2:1 and Freund's adjuvant was added according to the volume ratio of 1:1 to immunize animals as immunogens; at the same time, the glycoside injection developed by Jilin Whale Elephant Animal Pharmaceutical Co., Ltd. was used as Immunopotentiator, 5ml / bottle, to increase antibody titer.

[0054] Other steps are the same as in Example 1.

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Abstract

An immunoglobulin for preventing the reproduction-respiration syndrome and gyrate virus B of hog is prepared from their immunogens through cell culture, concentrating and proportionally mixing it with complete Frennd's adjuvant. It features that the glycoside-peptide injection is used as its immunopotentiator.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to a dual hyperimmune immunoglobulin against porcine reproductive and respiratory syndrome and porcine type 2 circovirus. The international patent classification number is A61K39 / 395. Background technique [0002] Porcine reproductive and respiratory syndrome and porcine circovirus type 2 are new infectious diseases that seriously endanger the pig industry in my country in recent years. These two diseases come from imported pigs and are newly introduced diseases in our country. Since our country is currently a new epidemic area, the prevalence and harm of these two diseases in our country are also relatively serious. It often results in abortion of sows and death of piglets in litters. Huge losses have been caused to the pig industry. [0003] Porcine reproductive and respiratory syndrome (Porcine reproductive and respiratory syndrome, PRRS), also known as blue ear disease...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K39/295A61K39/39A61P31/12
Inventor 张中洋
Owner 张中洋
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