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Functionalized quantum dot, process for preparation and use thereof

A quantum dot, functionalized technology, applied in chemical instruments and methods, measuring devices, instruments, etc., can solve the problems that quantum dots cannot be stored for a long time, the labeling rate is low, and cannot be popularized and applied on a large scale, and achieves high labeling efficiency. Simple method, good general effect

Inactive Publication Date: 2007-04-25
SHANXI LIFEGEN
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Problems solved by technology

[0012] The purpose of the present invention is to provide a functionalized quantum dot and its preparation method and application, which solves the technical problems that the labeling rate in the background technology is low, the functionalized quantum dot cannot be stored for a long time, and cannot be popularized and applied on a large scale

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  • Functionalized quantum dot, process for preparation and use thereof
  • Functionalized quantum dot, process for preparation and use thereof
  • Functionalized quantum dot, process for preparation and use thereof

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Embodiment Construction

[0048] The functionalized quantum dots of the present invention mainly refer to N-hydroxysuccinimide esterified quantum dots. The present invention uses HS-(CH 2 ) n COOH or mercaptoisopropionic acid is used as a stabilizer, and the quantum dots synthesized in the aqueous solution are transferred to an organic solvent, and under the action of dicyclohexylcarbodiimide (DCC), they react with N-hydroxysuccinimide to form Active ester derivatives react with amino groups on biomacromolecules with amino groups to form couplings covalently linked by amide bonds. Quantum dots can be detected by photoluminescence, which can be used for the analysis and detection of biomacromolecules with amino groups The fluorescent probes in , that is, fluorescent labeling agents, are used in biochips, molecular beacons, etc.

[0049] The structural formula of the functionalized quantum dot of the present invention is as follows:

[0050]

[0051] Among them, n=1, 2, 3, 4, 5, 6...

[0052] n=1,...

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Abstract

The invention relates to a kind of functional quanta spot. The producing procedure comprises the following steps: pretreating the quanta spot synthesized in stablizing agent; adding pretreated quanta spot to the dissolved N-hydroxyl succinimide then adding the dissolved cicyclohexylcarbodiimide to get the reacting solution; wrapping the solution with paper which can protect the solution from light and making the solution react on the shaker for at least 125h; packaging; evacuating and drying in freeze-vacuum concentrator to get the esterified quanta spot by N- hydroxyl succinimide. The invention has solved many technological problems in background skills such as low labeling rate, unable to keep the quanta for a long time and unable to extend the practical use. The product disclosed in the invention has many advantages: it's water-soluble so it's easier and more efficient to label the biomacromolecule; it has good stability and versatility; it can be preserved for a long time while keeping its physical and chemical qualities.

Description

technical field [0001] The present invention relates to a functionalized quantum dot and its functionalized method and use. It specifically relates to a quantum dot esterified by N-hydroxysuccinimide and its method and application by being esterified by N-hydroxysuccinimide. Background technique [0002] In recent years, nanotechnology has gradually merged into analytical science and greatly promoted the development of biological analysis. [0003] Quantum dots (quantum dots, QDs), also known as semiconductor nanocrystals, are semiconductor nanoparticles composed of II-VI or III-V elements with a diameter of about 2nm to 6nm, which can receive excitation light to generate fluorescence , with excellent spectral characteristics and photochemical stability. Individual quantum dot particles are susceptible to impurities and lattice defects, resulting in low fluorescence quantum yields. If it is used as the core, after being coated with another semiconductor material to form a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06G01N33/533
Inventor 李铮陈超任挺立颜桦
Owner SHANXI LIFEGEN
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