Chinese medicinal composition, its extract containing insect and its preparation

Abstract

A Chinese medicine for treating cardiovascular and cerebrovascular diseases is prepared from 12 Chinese-medicinal materials including scorpion, leech, centipede, ground beetle, ginseng, red peony root, borneol, etc through extracting, mixing and shaping. The extract of said insect components is prepared through breaking, extracting in water at 25-65 deg.C 1-3 times, separating liquid extract and dregs, extracting from the dregs in water at 70-100 deg.C 1-3 times, separating liquid extract and dregs, collecting liquid extract, concentrating and drying.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, an insect drug extract contained therein and a preparation method thereof. Background technique [0002] Coronary arteriosclerotic heart disease refers to the formation of plaques on the coronary artery wall, resulting in stenosis or blockage of the vessel lumen, causing myocardial ischemia and hypoxia. It and coronary artery spasm are classified into the category of ischemic heart disease. [0003] Professor Wu Yiling pioneered the use of TCM collateral disease theory to explore the pathogenesis of coronary heart disease, and applied five insect medicines, including scorpion, centipede, earth element, leech and cicada slough, to the treatment of coronary heart disease and angina pectoris, and successfully developed Tongxin Luo capsule, which has a unique curative effect on coronary heart disease, angina pectoris, cerebral throm...

AI Technical Summary

Problems solved by technology

[0004] Because there are many difficulties in the development and application of insect medicines, for example, most of the active ingredients are not completely clear, the extraction and refining methods are not yet mature, and there is a lack of reference substances, etc., so the traditional direct pulverization method is generally used in the existing production process Make insect medicine into powder and use it as medicine

However, the traditional pulverization process has the following problems: 1) the cell structure of the insect medicine cannot be destroyed, so it is difficult for the active ingredients in the medicinal material to fully release and dissolve through the cell membrane; 2) due to the influence of mechanical heat energy, the temperature of the material during the pulverization process It can reach more than 80°C, which has a negative impact on the stability of the protein active ingredients of insect medicines; 3) The difficulty of crushing different parts of insect medicines is different, resulting in uneven mixing due to particle differences, which affects the uniformity of product quality sex

Among these preparation methods, low-temperature extraction cannot completely extract the active ingredients, and water decoction (95-100°C) will destroy part of the active ingredients.

[0008] So far, no more ideal insect medicine extraction technology has been disclosed in the prior art, especially the insect medicine extraction technology combining low temperature extraction and high temperature extraction has not been disclosed