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Medicine composition for treating anxiety neurosis, and oral cavity disintegration preparation

A composition, technology of anxiety disorder, applied in the field of pharmaceutical composition for treating anxiety disorder

Active Publication Date: 2012-10-03
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there is no relevant report on oral dosage forms of tandospirone and its derivatives other than tablets

Method used

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  • Medicine composition for treating anxiety neurosis, and oral cavity disintegration preparation
  • Medicine composition for treating anxiety neurosis, and oral cavity disintegration preparation
  • Medicine composition for treating anxiety neurosis, and oral cavity disintegration preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] The capsule of embodiment 1 tandospirone (1000 capsules)

[0071] Tandospirone 3g (about 0.008mol)

[0072] Starch 200g

[0073] Microcrystalline Cellulose 5g

[0074] After the tandospirone hydrochloride and the starch are uniformly mixed by an equal increase method, then mixed with the microcrystalline cellulose, granulated, and packed into capsules, the capsules are obtained.

Embodiment 2

[0075] The granules of embodiment 2 tandospirone citrate (1000 bags of granules)

[0076] Tandospirone citrate 10g (about 0.17mol)

[0077] Lactose 730g

[0078] Mannitol 230g

[0079] 70% ethanol about 20ml

[0080] Stevioside 10g

[0081] Preparation method: Mix tandospirone citrate, lactose starch and mannitol by equal increase method, then mix with other excipients, and granulate.

Embodiment 3

[0082] The granules of embodiment 3 tandospirone citrate (1000 bags of granules)

[0083] Tandospirone citrate 5g (about 0.008mol)

[0084] Starch 2000g

[0085] Powdered sugar 2000g

[0086] Dextrin 2000g

[0087] Soluble starch 4000g

[0088] Stevioside 10g

[0089] Preparation method: Mix tandospirone citrate and dextrin by equal volume increasing method, then mix with other excipients, and granulate.

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PUM

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Abstract

A composite medicine in the form particle or oral disintegrating tablet for enxiety is prepared from tandopsirone or its derivative and the pharmacologically acceptable additive. Its oral disintegrating form is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating anxiety, which belongs to the field of medicine. technical background [0002] Anxiety is the most common emotional reaction and a central symptom of all neuroses. With the development of society and the accelerated pace of life, people's demand for anti-anxiety drugs is increasing day by day. The 5-HT receptor agonist drug—tandospirone (tandospirone, trade name: Xidejing) was successfully developed by Sumitomo Pharmaceutical Co., Ltd. of Japan. Approved for marketing in Japan in 1996, it is sold in the market in the form of ordinary tablets of tandospirone citrate, and there is no report about other dosage forms so far. [0003] Ordinary tablets need to be taken with the help of drinking water and swallowing actions. This dosage form is used for some acute patients with difficulty swallowing or special circumstances, such as the elderly, children, and comatose patients, and the patie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/506A61K9/00A61K9/20A61K9/48A61K9/14A61P25/22
Inventor 陈刚陈功政刁健代竹青
Owner SICHUAN CREDIT PHARMA
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