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Injection in large capacity of sodium sulfonate containing tanshinone óÄA and preparation method

A technology of injection and tanshinone, which is applied in the field of medicine, can solve the problems of unfavorable clinical use and slow resolubility, and achieve good pharmaceutical properties

Inactive Publication Date: 2007-02-21
JILIN SIHUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chinese patent application (application number 200310121026.3, publication number 1555791) discloses tanshinone IIA sodium sulfonate powder injection, but the inventors found that after adopting the patented technology to make powder injection, its resolubility is slower, which is unfavorable for clinical use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Prescription for large-volume injection containing sodium tanshinone IIA sulfonate (according to 1000ml):

[0045] Sodium Tanshinone IIA Sulfonate 10mg

[0046] Sodium chloride 15g

[0047] Water for injection up to 1000ml.

[0048] Get the sodium tanshinone IIA sulfonate of prescription quantity, add 500ml water for injection, stir and dissolve, add the sodium chloride of prescription quantity, stir and dissolve. Add 0.1% (w / v) activated carbon, add 1M hydrochloric acid solution or 1M sodium hydroxide solution to adjust the pH value to 6.0-7.0, heat to 70-80°C, stir for 10 minutes, cool to 40-50°C, and decarbonize by coarse filtration , add water for injection to 1000ml, adjust the pH value to 6.0-7.0, filter with 0.22μm microporous membrane, fill, each bottle can hold 50ml, 100ml, 200ml, 250ml, 500ml, 1000ml, seal, and sterilize at 115°C In 20 minutes, the injection solution of the present invention was obtained.

Embodiment 2

[0050] Prescription for large-volume injection containing sodium tanshinone IIA sulfonate (according to 1000ml):

[0051] Sodium Tanshinone IIA Sulfonate 4000mg

[0052] Sodium chloride 6g

[0053] Water for injection up to 1000ml.

[0054]Get the sodium tanshinone IIA sulfonate of prescription quantity, add 500ml water for injection, stir and dissolve, add the sodium chloride of prescription quantity, stir and dissolve. Add 0.1% (w / v) activated carbon, add 1M hydrochloric acid solution or 1M sodium hydroxide solution to adjust the pH value to 6.0-7.0, heat to 70-80°C, stir for 10 minutes, cool to 40-50°C, and decarbonize by phase filtration , add water for injection to 1000ml, adjust the pH value to 6.0-7.0, filter with 0.22μm microporous membrane, fill, each bottle can hold 50ml, 100ml, 200ml, 250ml, 500ml, 1000ml, seal, and sterilize at 115°C In 20 minutes, the injection solution of the present invention was obtained.

Embodiment 3

[0056] Prescription for large-volume injection containing sodium tanshinone IIA sulfonate (according to 1000ml):

[0057] Sodium Tanshinone IIA Sulfonate 40mg

[0058] Sodium chloride 12g

[0059] Water for injection up to 1000ml.

[0060] Get the sodium tanshinone IIA sulfonate of prescription quantity, add 500ml water for injection, stir and dissolve, add the sodium chloride of prescription quantity, stir and dissolve. Add 0.1% (w / v) activated carbon, add 1M hydrochloric acid solution or 1M sodium hydroxide solution to adjust the pH value to 6.0-7.0, heat to 70-80°C, stir for 10 minutes, cool to 40-50°C, and decarbonize by coarse filtration , add water for injection to 1000ml, adjust the pH value to 6.0-7.0, filter with 0.22μm microporous membrane, fill, each bottle can hold 50ml, 100ml, 200ml, 250ml, 500ml, 1000ml, seal, and sterilize at 115°C In 20 minutes, the injection solution of the present invention was obtained.

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Abstract

A high-capacity injection contains tanshinone IIA-sodium sulfonate and pharmacologically acceptable additive. Its preparing process is also disclosed.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine and relates to a large-capacity injection, in particular to a large-volume injection containing sodium tanshinone IIA sulfonate and a preparation method of the injection. 【Background technique】 [0002] Salvia miltiorrhiza (RADIX ET RHIZOMA SALVIAE MILTIORRHIZAE), as an important Chinese herbal medicine, has been included in many editions of "Chinese Pharmacopoeia". Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge. Excavated in spring and autumn, removed from sediment, and dried. Salvia Miltiorrhiza is bitter in nature, slightly cold; GUIXIN, Liver Meridian. It has the functions of dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstrual flow, clearing away heart-fire and relieving restlessness. For irregular menstruation, amenorrhea dysmenorrhea, accumulation of lumps in the abdomen, tingling pain in the chest and abdomen, hea...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61K9/08A61P9/10A61P43/00
Inventor 张玉梅
Owner JILIN SIHUAN PHARM CO LTD
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