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Pre-metered dry powder inhaler for moisture-sensitive medicaments

A dry powder inhaler, a predetermined amount of technology, applied in the field of dry powder inhaler

Active Publication Date: 2007-02-14
BOEHRINGER INGELHEIM INT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such prior art inhalers open the powder dose before the inhaler is ready for inhalation, thus exposing this dose to the surrounding environment and possibly moist air exhaled by the user

Method used

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  • Pre-metered dry powder inhaler for moisture-sensitive medicaments
  • Pre-metered dry powder inhaler for moisture-sensitive medicaments
  • Pre-metered dry powder inhaler for moisture-sensitive medicaments

Examples

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Embodiment Construction

[0028] DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0029] The present invention relates to DPIs loaded with moisture sensitive drugs, preferably comprising tiotropium, and describes dose release to achieve high levels of release FPD. Preferably, the DPI is a predetermined amount. In addition, the present invention addresses how this sensitive drug can be protected throughout all stages of storage, transport, dispensing, re-storage and final administration from the moment the dose is formed and sealed to the moment the user inhales the selected dose No moisture problem. Suitable dry powder inhalers for moisture sensitive drugs are also disclosed.

[0030] The present invention discloses a dry moisture-proof, direct loading and sealing container containing a dose of tiotropium in a high FPD formulation containing at least one excipient. The term "tiotropium" is a generic term for all its active forms, including pharmaceutically acceptable salts (especi...

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Abstract

The invention discloses a medical product for use in a treatment of respiratory disorders, and comprises a metered dose of a tiotropium dry powder formulation, directly loaded and sealed into a container made to act as a dry high barrier seal to prevent the capture and ingress of moisture into the tiotropium powder. The dose of tiotropium is further adapted for inhalation and the container is so tight that the efficacy of the dose when delivered is unaffected by moisture. In a further aspect of the invention a type of inhaler is illustrated, which may accept at least one sealed, moisture-tight container of a dose of tiotropium, to deliver the dose with a consistent fine particle dose, over the expected shelf life of the product.

Description

Field of Invention [0001] The present invention relates to dry powder inhalers (DPIs) that deliver high and stable doses of fine particles. The inhaler utilizes a highly hermetically sealed container containing at least one metered dose of a formulation comprising at least one excipient and the tiotropium drug. [0002] Additional advantages and other features of the invention will be set forth, in part, in the description that follows, and in part will become apparent to those of ordinary skill in the art from a review of the following, or may be learned by practice of the invention. The advantages of the invention may be realized and attained as particularly pointed out in the appended claims. As will be realized, the present invention is capable of other and different embodiments, and its several embodiments are capable of modifications in various obvious respects, all without departing from the present invention. This description is to be considered illustrative in natur...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/72A61M15/00A61J1/00A61K31/46A61P11/06A61P11/08A61K9/00A61K31/4745
CPCA61K31/4745A61K9/0075A61K9/008A61K31/439A61P11/00A61P11/06A61P11/08A61K31/4748A61J1/00
Inventor M·迈尔曼S·卡兰德A·尼米
Owner BOEHRINGER INGELHEIM INT GMBH
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