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Traditional Chinese medicine composition for lowering blood fat, and prepn. method therefor

A composition and blood lipid-lowering technology, applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of no strict quality control methods in the drug production process, prone to fatal stroke, poor product quality and reliability, etc., to achieve Prevention and treatment of occurrence and development, controllable production process, and low manufacturing cost

Inactive Publication Date: 2007-02-14
湖南恒伟药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicines have large side effects. For example, according to foreign data, western statins accounted for 86.8% of the world's lipid-lowering drug market in 2004. However, the latest research found that statins not only fail to benefit patients with severe diabetes, but have May be more prone to fatal stroke
There are hundreds of types of traditional Chinese medicine lipid-lowering drugs reported in Chinese patent literature, but the production process of these drugs does not have strict quality control methods, the quality and reliability of the obtained products are poor, or the curative effect is not very satisfactory, which cannot satisfy patients
[0004] At present, there is no generally accepted ideal drug for lowering blood lipids. In addition to the above, there are several important disadvantages: one is that long-term use can damage liver function; the other is that blood lipids rise quickly after stopping the drug ; The third is that the recipes are mostly complicated and the manufacturing cost is higher

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Prescription: Hawthorn (pitted) 1700g, Polygonum multiflorum 84g, Cassia seed 84g, lotus leaf 250g, Alisma 110g.

[0015] Preparation method: (1) Decoct the weighed hawthorn and cassia seeds with water twice, 2 hours each time, combine the decoction, filter, and concentrate the filtrate to a thick paste with a relative density of 1.28-1.30 (80°C), and set aside; (2) Prepare Radix Polygoni Multiflori, lotus leaf and add dilute ethanol to reflux extraction 3 times, the first 3 hours, the second 2 hours, the third 1 hour, combine the extracts, filter, the filtrate reclaims ethanol, concentrates to a relative density of 1.28~1.30 (80℃) thick paste, set aside; (3) Grind Alisma alisma into fine powder, sieve, combine with the above thick paste, mix well, dry under reduced pressure, crush, and sieve; (4) Pack Capsules, made into 1000 capsules, ready to serve.

Embodiment 2

[0017] Prescription: Hawthorn (pitted) 1928g, Polygonum multiflorum 50g, Cassia seed 60g, Lotus leaf 130g, Alisma 60g.

[0018] Preparation method: (1), (2), (3) are the same as in Example 1; (4) add micropowder silica gel, microcrystalline cellulose, granulate with 10% starch slurry, sieve, low temperature (50-60°C ) drying, granulation (20-60 mesh), adding magnesium stearate, mixing, tableting, made into 1000 tablets, film-coated, and ready to serve.

Embodiment 3

[0020] Prescription: Hawthorn (pitted) 1458g, Polygonum multiflorum 120g, Cassia seed 120g, Lotus leaf 370g, Alisma 160g;

[0021] Preparation method: (1), (2), (3) are the same as in Example 1; (4) add dextrin and stevioside, mix well, dry, and make 1000g of granules, and it is ready.

[0022] 76 cases of primary hyperlipidemia were treated with the product of Example 1 (trade name "Jiangzhining" capsules), and Gypenoside capsules were used as a control over the same period. The effect of adjusting blood lipids and the changes in hemorheology indicators were observed as follows.

[0023] (1) Diagnostic criteria

[0024] Refer to the diagnostic criteria formulated by the Ministry of Health and the State Administration of Traditional Chinese Medicine Geriatric Medicine Research Collaborative Group: (1) total cholesterol (TC) ≥ 5.70mmol / L; (2) triglyceride (TG) ≥ 1.7mmol / L; ( 3) High-density lipoprotein cholesterol (HDL-C) ≤ 1.03mmol / L for men and ≤ 1.16mmol / L for women; (4) Lo...

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PUM

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Abstract

A Chinese medicine for decreasing blood fat, softening blood vessel, and treating arrhythmia and hyperlipemia is proportionally prepared from haw, prepared fleece flower root, cassia seed, lotus leaf and alismatis rhizome. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a blood lipid-lowering traditional Chinese medicine composition and a preparation method thereof, in particular to a blood fat-lowering traditional Chinese medicine herbal medicine composition and a preparation method thereof. Background technique [0002] About 2.6 million people die from cardiovascular and cerebrovascular diseases in my country every year, with an average of 300 deaths per hour. The mortality rate of cardiovascular and cerebrovascular diseases has exceeded 1 / 2 of the total death rate of the population. Hyperlipidemia is one of the main risk factors for cardiovascular and cerebrovascular diseases. Scientific research at home and abroad has made it clear that hyperlipidemia is the prelude to cardiovascular and cerebrovascular diseases, the main risk factor leading to atherosclerosis, and the "culprit" of cardiovascular and cerebrovascular diseases and related diseases. [0003] Exis...

Claims

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Application Information

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IPC IPC(8): A61K36/884A61P3/06
Inventor 吕宏再
Owner 湖南恒伟药业股份有限公司
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