Eye drop composition

Abstract

An eye drop composition which contains a quaternary ammonium salt in a reduced amount and, despite this, has a sufficient antiseptic effect. The composition contains nipradilol as a medicinal ingredient and is characterized by containing 0.0005 to 0.005% by mass cationic surfactant which is a quaternary ammonium salt.

Description

technical field [0001] The present invention relates to an eye drop composition, and more particularly to an eye drop composition having high safety to eyes and excellent antiseptic effect and containing nipradilol. Background technique [0002] Eye drops are solutions, suspensions of pharmaceuticals, or preparations that are applied to the conjunctival sac after dissolving or suspending pharmaceuticals during use, and are required to be sterile. [0003] Therefore, eye drops are usually produced by filling a filter-sterilized drug in a sterilized container under a clean environment, and they are in a sterile state before opening. However, when the patient uses it, since the outer plug is removed and the inner liquid is added dropwise, non-sterile external air will flow into the container, and if the inner liquid does not contain preservatives, the inner liquid may be contaminated by microorganisms. [0004] Therefore, the preservatives represented by quaternary ammonium sa...

AI Technical Summary

Problems solved by technology

[0006] However, the effective concentration of the quaternary ammonium salt cationic surfactant is about 0.01% as mentioned above, and it is considered unrealistic to reduce the amount of the cationic surfactant, that is, to reduce the preservative.

In this way, it is extremely difficult to reduce the compounding amount of the quaternary ammonium salt, which can widely prevent the proliferation of various microorganisms and also cause damage to the cornea, etc.