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Pharmaceutical composition containing pemetrexed

A pemetrexed and composition technology, applied in the field of pharmaceutical compositions containing pemetrexed, can solve problems such as poor solubility, sensitivity, and instability of pemetrexed, achieve color stability, avoid degradation, and preserve long term effect

Inactive Publication Date: 2007-02-07
NANJING YINUOWEI PHARM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the above shortcomings of pemetrexed, which are unstable, easily degraded, sensitive to light, heat and humidity, and poor in solubility, and provide a stable, room-temperature-placeable and auxiliary material containing pemetrexed. readily available pharmaceutical composition

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Pemetrexed disodium 500g, arginine 100g, mannitol 350g and water for injection are prepared into a 5.0L solution, the pH value is adjusted to about 5.5, the pyrogen is removed, subpackaged, and freeze-dried to obtain the product.

Embodiment 2

[0027] Pemetrexed disodium 500g, methionine 100g, glycine 300g, mannitol 250g and water for injection were prepared into a 5.0L solution, adjusted to a pH value of about 8.5, depyrogenated, subpackaged, and freeze-dried to obtain the product.

Embodiment 3

[0029] Pemetrexed disodium 500g, glycine 150g, mannitol 350g and water for injection are prepared into a 5.0L solution, the pH value is adjusted to about 6, the pyrogen is removed, subpackaged, and freeze-dried to obtain the product.

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PUM

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Abstract

The invention discloses a drug composition with Peimeiqusai and stabilizer at 5: 2-7, wherein the weight rate of Peimeiqusai and shaping agent is 0.5-1: 1. The invention is stable for light and heat, which can be reserved at normal temperature.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing pemetrexed. Background technique [0002] Pemetrexed is a novel pyrrole[2,3-d]pyrimidine-based antifolate substance. The chemical name is N-[4[2(amino3,4dihydro-4-keto-1H-pyrrole[2,3-d]pyrimidine-5-hydroxy)ethyl]-benzoyl]-L-glutamic acid di Sodium salt, the pyrazine ring in the pteridine folic acid moiety is replaced by a pyrrole ring, and the benzyl nitrogen of the bridging moiety is replaced by a methyl group. Its anhydrous substance is off-white to light gray-green amorphous powder, which is hygroscopic and easy to absorb water to form a stable heptahydrate. The appearance is light green to green crystalline powder. [0003] It is currently known that certain anti-folate metabolism drugs have anti-tumor effects, and these compounds achieve anti-tumor purposes by inhibiting the enzyme conversion that is dependent on folic acid metabolism....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K9/08A61K47/18A61P35/00
Inventor 许凯
Owner NANJING YINUOWEI PHARM TECH
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