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Bioabsorbable polymeric granular porous bone filling material and production method thereof

A bioabsorption and filling material technology, applied in dental preparations, tissue regeneration, pharmaceutical formulations, etc., can solve the problems of low crushing efficiency, difficulty in industrial crushing, and inability to obtain granular materials, and achieve high bioabsorption performance.

Inactive Publication Date: 2007-01-31
GC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the conventional production method of biodegradable polymer materials with a porous structure produces materials in a mold with a fixed size, so there is a problem that only foam-type, sponge-type blocks, etc. can be produced, and granular materials cannot be obtained
That is, since the bulk material is a soft substance with a porous structure, there are technical limitations in thinning it in the affected area for medical treatment, which also increases the possibility of infection
In addition, it is also difficult to industrially pulverize biodegradable soft polymer materials with a porous structure, and the pulverization efficiency is quite low
[0007]Furthermore, since most of these biodegradable polymer materials are applied in tissue engineering by seeding living cells therein, there exists the possibility that these materials are too soft and The problem of poor formability, because the pore size of the foam-type or sponge-type porous structure of these materials is about 180-500 μm, which is much larger than the size of the cell

Method used

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  • Bioabsorbable polymeric granular porous bone filling material and production method thereof
  • Bioabsorbable polymeric granular porous bone filling material and production method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] A polymer material containing sodium chloride that is approximately uniformly mixed is obtained by adding a copolymer of lactic acid and glycolic acid (lactic acid: glycolic acid=75:25, with a weight average molecular weight of about 250,000) in dioxane Medium to concentration of 12% by weight, use a stirrer to stir to dissolve, sodium chloride powder (particle size is 300-700 μm) and dioxane solution dissolved in lactic acid and glycolic acid copolymer are approximately uniformly mixed to The concentration of sodium chloride is about 1.18g / cm 3 , pour it into a mold, use a refrigerator (MDf-0281AT produced by Sanyo Electric Corporation) to freeze at -30 ° C, and then use a vacuum dryer (DP43 produced by Yamato Scientific Corporation) to dry under reduced pressure for 48 hours to remove oxygen Heterocyclohexane. Then, by cutting the polymer into small pieces, pulverizing the small pieces using a planetary ball mill for 50 minutes, adding the pulverized polymer to the f...

Embodiment 2

[0030] Obtain the polymeric material that contains the sodium chloride that mixes approximately uniformly by following method: polyglycolic acid (weight average molecular weight is about 200000) is added in the dichloromethane to concentration and is 9% by weight, uses stirrer to stir to make it dissolve, and Pour the dichloromethane solution of polyglycolic acid into the mold that has been added with sodium chloride powder (particle size 300-700 μm) to a sodium chloride concentration of about 1.18g / cm 3 , using a refrigerator (MDf-0281AT produced by Sanyo Electric Corporation) to freeze at -30°C, and then drying under reduced pressure using a vacuum dryer (DP43 produced by Yamato Scientific Corporation) for 48 hours to remove dichloromethane. Then, by cutting the polymer into small pieces, pulverizing the small pieces using a planetary ball mill for 20 minutes, adding the pulverized polymer to a flask, adding distilled water to the flask, stirring to remove sodium chloride, an...

Embodiment 3

[0032] Obtain the polymer material that contains the potassium chloride of homogeneous mixing by following method: the copolymer of lactic acid and glycolic acid (lactic acid: glycolic acid=75:25, weight average molecular weight is about 250000) joins dioxane Medium to concentration of 12% by weight, use a stirrer to stir to dissolve it, pour the dioxane solution of lactic acid and glycolic acid copolymer into the mold that has been added with potassium chloride powder (particle size is about 400 μm) To potassium chloride concentration of about 1.08g / cm 3 , was frozen at -30°C using a refrigerator (MDf-0281AT manufactured by Sanyo Electric Corporation), and then dried under reduced pressure using a vacuum dryer (DP43 manufactured by Yamato Scientific Corporation) for 48 hours to remove dioxane. Then, cut the polymer into small pieces, pulverize the small pieces for 50 minutes using a planetary ball mill, add the pulverized polymer into a flask, add distilled water into the fla...

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Abstract

A bioabsorbable granular porous bone filling material having a particle diameter 100 to 3000 µm used for filling a defect part after removing a lesion, or grafting a self bone, and for reinforcing or filling a jawbone when embedding a dental implant, is produced such that the polymer material containing a particle-shaped material and having the small hole structure with the hole diameter of 5 to 50 µm is made by mixing the particle-shaped material having a diameter of 100 to 2000 µm with a solution, where the bioabsorbable polymer is dissolved with an organic solvent, the particle-shaped material being not dissolved with this organic solvent but dissolved with a liquid not dissolving the bioabsorbable polymer, freezing it, drying it to remove the organic solvent, pulverizing the produced material, dissolving the particle-shaped material with the liquid to be removed, and sieving it.

Description

technical field [0001] The invention relates to a bioabsorbable granular porous bone filling material and a preparation method thereof. This material is used to fill defects after excision of lesions caused by diseases such as osteoma and osteomyelitis, and after autologous bone grafting. It is also used to reinforce and fill gums when implanting teeth. Background technique [0002] As artificial bone materials, inorganic materials such as hydroxyapatite ceramics, tricalcium phosphate ceramics, calcium phosphate-based glass and the like are generally used. The shape of the artificial bone material used to fill the defect is generally rod or block, but the granular shape is also widely used, because the granular shape can fill various parts of the defect and can be applied to the defect of any shape. [0003] Particulates obtained by pulverizing the above-mentioned inorganic materials (for example, refer to Japanese Patent Publication Nos. 1994-339519, 2002-58735, and 2004-2...

Claims

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Application Information

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IPC IPC(8): A61L27/00A61L27/56A61L27/58A61K6/08C08J9/00A61K6/884
CPCA61L27/58A61L2430/02A61L27/18A61L27/56C08L67/04
Inventor 山本克史山中克之须田洋子金子正
Owner GC CORP
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