Medicine composition for treating biliary tract calculus, prepn. method and use thereof

A technology for bile duct stones and compositions, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as difficulty in identifying symptoms, undisclosed amounts of raw materials, usage of drugs, and different indications. , to achieve the effect of feasible preparation process, stable quality and reasonable formulation

Inactive Publication Date: 2007-01-31
SICHUAN XUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are related reports about "Gan Gall Stone Tablets", such as: Clinical Observation of 85 Cases of Hepatolithiasis Treated by Gan Gall Stone Tablets, Zhejiang Journal of Traditional Chinese Medicine (1999, 34 (7); Research on the Treatment of Cholelithiasis with Liver Gall Stone Tablets , Journal of Traditional Chinese Medicine, 1997, 38(3); Effects of Hepatolithiasis Tablets on Animal Inflammation and Bile Components, Journal of Traditional Chinese Medicine, 1998, 9(5); Litholysis, Antibacterial and Antispasmodic Effects of Hepatolithiasis in Vitro, Chinese Pharmacy 1998, September (2), which disclosed that the liver and gallbladder tablets were composed of ox gall water, fire salt, gallinaceous gold, citrus aurantii, Cyperus cyperi, woody, corydalis, coptis, Atractylodes macrocephala, evodia and other raw materials, but did not disclose The amount of raw materials and the usage of drugs, according to the theory of traditional Chinese medicine, different etiologies, pathogenesis, and different medicines in traditional Chinese medicine, without disclosing the amount of raw materials, it is difficult to know the disease it targets. Therefore, the usage and dosage of raw materials determine For the indications, the dosage of the same raw material is different, and the indications may be different

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 The preparation of medicine of the present invention

[0026] 1. Prescription:

[0027] 173g of ox gall water, 115g of fire salt, 133g of gallinaceous gold (stir-fried), 52g of citrus aurantii (stir-fried with bran), 68g of Cyperus cyperi (made), 34g of woody fragrance, 34g of Corydalis (made with vinegar), 21g of Coptis chinensis, Atractylodes macrocephala (stir-fried with bran) ) 68g, Evodia (stir-fried) 27g, galangal 41g, hawthorn (stir-fried) 68g, Jianqu 141g, Qingpi 34g;

[0028] Excipients: starch 4%, magnesium stearate 1%.

[0029] The above raw and auxiliary materials are made into 1000 gallstone tablets altogether.

[0030] 2. Process and operation

[0031] (1) Take stir-fried chicken neigold, Jianqu and fire salt, mix them, pulverize them according to the "Technical Safety Operation Method for Crushing Posts", pass through a 120-mesh sieve, and finely powder them for later use.

[0032] (2) Take green bark, woody fragrance, Atractylodes macroc...

Embodiment 2

[0046] Embodiment 2 The preparation of medicine of the present invention

[0047] a. Weigh the raw materials with the following weight proportions: 300g of ox gallbladder water, 150g of fire salt, 200g of gallinaceous gold, 90g of Citrus aurantium, 100g of Cyperus cyperi, 50g of woody incense, 55g of Corydalis Corydalis, 40g of Coptidis Rhizome, 120g of Atractylodes macrocephala, 45g of Evodia rutaecarpa, Galangal 80g, Hawthorn 120g, Jianqu 200g, Qingpi 60g; (The raw materials can use processed products or not)

[0048] b. Take gallinaceous gold and fire salt and grind them into fine powder, set aside;

[0049] c. Take Jianqu and crush it;

[0050] d. Heat the ox gall water to boiling, filter, and concentrate the filtrate to obtain a clear paste;

[0051] e. Extract volatile oil from green bark, woody scent, Atractylodes macrocephala, Citrus aurantii, Cyperus cyperi, Evodia rutaecarpa, and galangal by steam distillation. The volatile oil is included with β-cyclodextrin, and ...

Embodiment 3

[0053] Embodiment 3 The preparation of medicine of the present invention

[0054] a. Weigh the following raw materials in the following weight ratio: 150g of ox gall water, 100g of fire salt, 100g of gallinaceous gold, 30g of Citrus aurantium, 30g of Cyperus cyperi, 20g of woody fragrance, 20g of Corydalis Corydalis, 10g of Coptidis Rhizome, 40g of Atractylodes macrocephala, 10g of Evodia rutaecarpa, Galangal 20g, Hawthorn 40g, Jianqu 120g, Qingpi 20g;

[0055] b. Take gallinaceous gold and fire salt and grind them into fine powder, set aside;

[0056] c. Take Jianqu and heat water for extraction to obtain hot water extract;

[0057] d. Heat the ox gall water to boiling, filter, and concentrate the filtrate to obtain a clear paste;

[0058] e. Extract volatile oils from green bark, woody scent, Atractylodes macrocephala, Citrus aurantii, Cyperus cyperi, Evodia rutaecarpa, and galangal by supercritical flow. The volatile oils are encapsulated with β-cyclodextrin, and the incl...

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Abstract

A Chinese medicine for treating cholelithiasis is prepared from 14 Chinese-medicinal materials including ox gall, cyprus tube, coptis root, haw, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating biliary calculus, which is a pharmaceutical composition prepared from Chinese medicinal materials and belongs to the field of medicines. Background technique [0002] Among the world's medical metabolic diseases, hepatolithiasis is on the rise year by year, seriously threatening human health. As of 1990, the natural population incidence of hepatolithiasis was 10% in my country [1], 10% in the United States, 17.3% in Japan, and 18% in Germany [2]. In my country, bilirubin-based stones account for 40%, while in rural areas, bilirubin-based stones account for 68%, which is a more serious threat to the health of rural people. [3] In 1971, Thistle and Schoenfield reported that CDCA successfully dissolved cholesterol stones, thus establishing oral stone-dissolving therapy as a part of modern internal medicine [4], but soon German Professor Dr. A. SCHROEDTER pointed out: "CDCA stone-dissolvin...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61P1/16A61K35/413A61K35/38A61K33/00A61K35/57
Inventor 谢石方
Owner SICHUAN XUHUA PHARMA
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