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Guhong control-release tablets and prepn. method therefor

A technology of controlled-release tablets and safflower, applied in the field of controlled-release tablets, can solve the problems such as the inability to guarantee the dissolution rate of acetoglutamine, the difficulty in the release rate of bioavailability, and the inability to guarantee the dissolution rate of acetoglutamine.

Active Publication Date: 2012-06-27
TONGHUA TELI JIER PHARM TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, for intravenous infusion, the bioavailability of Guhong injection is 100%. Compared with oral preparations, how to make the active ingredients in Guhong injection absorbed through the digestive tract and released in a relatively stable way? The production of the oral preparation itself is not difficult, but it is very difficult to ensure the high bioavailability and stable release rate of the oral preparation of Guhong
[0006] The inventor found in the research and development process of Guhong controlled-release tablets that if the types and proportions of specific preparation auxiliary materials cannot be obtained by groping, the dissolution rate of acetylglutamine in Guhong controlled-release tablets cannot be guaranteed. The dissolution rate of glutamine cannot be guaranteed, which may be related to the composition and properties of the safflower extract in the Guhong preparation, and solving the dissolution problem of acetylglutamine has become the biggest problem faced by the Guhong preparation to respond to the clinical needs of oral administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] prescription:

[0024] Safflower 5000g Acetyl Glutamine 300g Sucrose Monocaprylate 200g

[0025] Stearic acid 150g Lactose 100g

[0026] Preparation:

[0027] (1) Take safflower, add 6-10 times the amount of water to decoct 3 times, add 10 times the amount of water to decoct for 1 hour for the first time, add 8 times the amount of water to decoct for 50 minutes for the second time, add 6 times the amount of water for the third time Double the amount of water and decoct for 30 minutes, combine the decoction, filter, concentrate the filtrate to a relative density of 1.16-1.26, add ethanol to make the alcohol content reach 70%, refrigerate, let stand for 48 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density The density is 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand for 48 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.16-1.20, add 10 times the amount ...

Embodiment 2

[0030] prescription:

[0031] Safflower 5000g Acetyl Glutamine 300g Sucrose Monolaurate 200g

[0032] Stearic acid 150g Lactose 100g

[0033] Preparation:

[0034] (1) Take safflower, add 6-10 times the amount of water to decoct 3 times, add 10 times the amount of water to decoct for 1 hour for the first time, add 8 times the amount of water to decoct for 50 minutes for the second time, add 6 times the amount of water for the third time Double the amount of water and decoct for 30 minutes, combine the decoction, filter, concentrate the filtrate to a relative density of 1.16-1.26, add ethanol to make the alcohol content reach 70%, refrigerate, let stand for 48 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density The density is 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand for 48 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.16-1.20, add 10 times the amount of...

Embodiment 3

[0037] prescription:

[0038] Safflower 5000g Acetyl Glutamine 300g Sucrose Monopalmitate 100g

[0039] Stearic acid 100g Lactose 60g

[0040] Preparation:

[0041] (1) Take safflower, add 6-10 times the amount of water to decoct 3 times, add 10 times the amount of water to decoct for 1 hour for the first time, add 8 times the amount of water to decoct for 50 minutes for the second time, add 6 times the amount of water for the third time Double the amount of water and decoct for 30 minutes, combine the decoction, filter, concentrate the filtrate to a relative density of 1.16-1.26, add ethanol to make the alcohol content reach 70%, refrigerate, let stand for 48 hours, filter, recover the ethanol from the filtrate and concentrate to a relative density The density is 1.10-1.14, add ethanol to make the alcohol content reach 80%, refrigerate, stand for 48 hours, filter, recover ethanol from the filtrate and concentrate to a relative density of 1.16-1.20, add 10 times the amount o...

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PUM

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Abstract

A release controllable Guhong tablet is prepared from acetylglutamine, safflower, cane sugar, ester of fatting acid, stearic acid and lactose. Its preparing process is also disclosed.

Description

technical field [0001] The present invention relates to Guhong preparation, specifically a kind of Guhong controlled-release tablet, and more specifically relates to a safflower extract obtained by extracting the Chinese herbal medicine safflower and then mixed with acetylglutamine, sucrose fatty acid ester and stearic acid. Controlled-release tablets formulated with lactose. Background technique [0002] Acetylglutamine is N 2 -Acetyl-L-glutamine (C 7 h 12 N 2 o 4 ), which is a white crystalline powder, is often used clinically as a drug for improving brain function. The drug can pass through the blood-cerebrospinal fluid barrier, and after passing through the blood-cerebrospinal fluid barrier, it can be decomposed into glutamic acid and gamma-aminobutyric acid (GABA) to play a role. Glutamic acid participates in the information transmission of the central nervous system. γ-aminobutyric acid can antagonize the excitatory toxicological effect of glutamic acid, improve ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K36/286A61K31/198A61K47/14A61K47/24A61K47/12A61P9/10A61P7/02A61P1/16A61P25/00
Inventor 张玉梅
Owner TONGHUA TELI JIER PHARM TECH SERVICE CO LTD
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