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Medicine for treating cardiovascular disease and its preparing method and quality control method

A cardiovascular and drug technology, applied in the field of quality control of drugs for the treatment of cardiovascular diseases and their preparation methods, can solve the problems of large dosage, inconvenient dosage, inaccurate dosage, etc.

Inactive Publication Date: 2007-01-24
JINSHAN MONGOLIA MEDICINE FACTORY AOTEQI MONGDIA MEDICIEN INNER MONGOLIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The original dosage form is decoction, and there is no specific prescription ratio, which has the defects of inaccurate dosage, large dosage, inconvenient dosage, poor taste and extremely difficult quality control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The present invention is made up of the following components by weight ratio: Jujube 1120g, Sophora flavescens 2240g, Myrobalan 112g Preparation method:

[0068] Pulverize myrobalan into a fine powder; pulverize jujube into a coarse powder, extract twice, add 6 times the amount of 70% ethanol to reflux for 1.5 hours each time, filter, combine the filtrates, recover ethanol, and concentrate to a relative density of ~1.30 (60 ℃); Sophora flavescens is crushed into coarse powder, extracted twice, each time adding 8 times the amount of 60% ethanol to reflux for 2 hours, filtering, combining the filtrates, recovering ethanol, and concentrating to a relative density of 1.25-1.30 (60°C); Combine the above two thick extracts, add Myrobalan fine powder, mix well, vacuum dry at 70°C, pulverize, mix well, add conventional pills with auxiliary materials, and make water pills 500g (1g per 10 pills).

Embodiment 2

[0070] The present invention is made up of the following components by weight ratio: Jujube 1120g, Sophora flavescens 1120g, Myrobalan 336g Preparation method:

[0071] Grind Myrobalan into coarse powder, extract 3 times, add 6 times of 50% ethanol each time, reflux for 1 hour, filter, combine filtrate, recover ethanol, concentrate to relative density 1.20~1.30 (60°C); Grind into a coarse powder, extract twice, add 6 times the amount of 70% ethanol each time, reflux for 1.5 hours, filter, combine the filtrate, recover ethanol, concentrate to a relative density of 1.25-1.30 (60°C); powder, extracted twice, each time adding 8 times the amount of 60% ethanol to reflux for 2 hours, filtering, combining the filtrate, recovering ethanol, concentrating to a relative density of 1.25-1.30 (60°C); combining the above three thick extracts, Mix evenly, vacuum dry at 70°C, pulverize, mix evenly, add conventional excipients for granules, and make 500g (1.5g / bag) of granules according to the...

Embodiment 3

[0073] The present invention is made up of the following components by weight ratio: Jujube 1120g, Sophora flavescens 1120g, Myrobalan 140g Preparation method:

[0074]Pulverize myrobalan into a fine powder; pulverize jujube into a coarse powder, extract twice, add 6 times the amount of 70% ethanol to reflux for 1.5 hours each time, filter, combine the filtrates, recover ethanol, and concentrate to a relative density of ~1.30 (60 ℃); Sophora flavescens is crushed into coarse powder, extracted twice, each time adding 8 times the amount of 60% ethanol to reflux for 2 hours, filtering, combining the filtrates, recovering ethanol, and concentrating to a relative density of 1.25-1.30 (60°C); Combine the above two thick extracts, add Myrobalan fine powder, mix well, vacuum dry at 70°C, pulverize, mix well, add conventional auxiliary materials for hard capsules, and make 1000 hard capsules.

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Abstract

The present invention relates to a kind of medicine for treating cardiac vascular diseases and its preparation process and quality control method. The medicine is prepared with axillary choerospondias fruit, flavescent sophora root and myrobalan fruit. The medicine of the present invention can improve myocardial ischemia obviously, increase the blood flow of coronary artery, eliminate or remite coronary heart disease and angina symptoms, regulate and improve cardiac vascular system, inhibit platelet aggregation, prevent thrombosis and lower blood viscosity.

Description

Technical field: [0001] The invention relates to a medicine for treating cardiovascular diseases and a method for quality control of its preparation method, in particular to a medicine preparation made of jujube, flavescens and chebula according to the weight ratio, which belongs to the technology of medicine and its preparation field. Background technique: [0002] The basic pathological basis of coronary heart disease angina pectoris is coronary atherosclerosis or coronary artery spasm, resulting in stenosis or even blockage of the vascular lumen, causing an imbalance between myocardial oxygen supply and demand, resulting in myocardial ischemia, hypoxia or necrosis. Modern Chinese medicine calls it The main symptoms of coronary heart disease angina pectoris are chest tightness, shortness of breath, paroxysmal heart pain, palpitations, and shortness of breath. [0003] In recent years, the morbidity and mortality of coronary heart disease in China have shown a rapid upward...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/02A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P9/10A61P7/02G01N30/90G01N33/15
Inventor 杨阿敏赵家栋
Owner JINSHAN MONGOLIA MEDICINE FACTORY AOTEQI MONGDIA MEDICIEN INNER MONGOLIA
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